亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

MRI Predicts Residual Disease and Outcomes in Watch-and-Wait Patients with Rectal Cancer

医学 结直肠癌 残余物 疾病 放射科 癌症 内科学 算法 计算机科学
作者
Hannah Williams,Dana M. Omer,H Thompson,Sabrina T. Lin,Floris S. Verheij,João Miranda,Jonathan B. Yuval,James G. Buckley,Michael R. Marco,Li‐Xuan Qin,David Dombroski,R P Kedar,Aytekin Oto,Elena Korngold,Joseph C. Veniero,Sunil Gandhi,Arun Krishnaraj,Minal Jagtiani Sangwaiya,Kirk Ohanian,Dan Vu
出处
期刊:Radiology [Radiological Society of North America]
卷期号:312 (3) 被引量:4
标识
DOI:10.1148/radiol.232748
摘要

Background MRI plays a crucial role in restaging locally advanced rectal cancer treated with total neoadjuvant therapy (TNT); however, prospective studies have not evaluated its ability to accurately select patients for nonoperative management. Purpose To evaluate the ability of restaging MRI to predict oncologic outcomes and identify imaging features associated with residual disease (RD) after TNT. Materials and Methods This was a secondary analysis of the Organ Preservation in Rectal Adenocarcinoma (OPRA) trial, which randomized participants from April 2014 to March 2020 with stages II or III rectal adenocarcinoma to undergo either induction or consolidation TNT. Participants enrolled in the OPRA trial who underwent restaging MRI were eligible for inclusion in the present study. Radiologists classified participants as having clinical complete response (cCR), near-complete clinical response (nCR), or incomplete clinical response (iCR) based on restaging MRI at a mean of 8 weeks ± 4 (SD) after treatment. Oncologic outcomes according to MRI response category were assessed using Kaplan-Meier curves. Logistic regression analysis was performed to identify imaging characteristics associated with RD. Results A total of 277 participants (median age, 58 years [IQR, 17 years]; 179 male) who were randomized in the OPRA trial had restaging MRI forms completed. The median follow-up duration was 4.1 years. Participants with cCR had higher rates of organ preservation compared with those with nCR (65.3% vs 41.6%, log-rank
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
笨笨完成签到,获得积分10
1秒前
vchen0621完成签到,获得积分0
6秒前
certe完成签到,获得积分10
8秒前
10秒前
vchen0621发布了新的文献求助10
13秒前
先玩了玉完成签到,获得积分10
16秒前
俞无声完成签到 ,获得积分10
18秒前
花凉发布了新的文献求助20
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
研友_VZG7GZ应助科研通管家采纳,获得10
1分钟前
1分钟前
尊敬夜南完成签到,获得积分10
1分钟前
Cathy完成签到 ,获得积分10
1分钟前
今天看文献了吗完成签到,获得积分10
1分钟前
张晓祁完成签到,获得积分10
2分钟前
yueying完成签到,获得积分10
2分钟前
2分钟前
Owen应助尊敬夜南采纳,获得10
2分钟前
花凉完成签到,获得积分10
3分钟前
花凉发布了新的文献求助20
3分钟前
Ava完成签到,获得积分10
3分钟前
liudy完成签到,获得积分10
3分钟前
Ava发布了新的文献求助50
3分钟前
吃了吃了完成签到,获得积分10
3分钟前
liudy发布了新的文献求助10
3分钟前
领导范儿应助科研通管家采纳,获得10
3分钟前
4分钟前
阿紫吖完成签到 ,获得积分10
4分钟前
过时的白曼完成签到,获得积分10
4分钟前
隐形曼青应助三叔采纳,获得10
4分钟前
4分钟前
陈苗发布了新的文献求助10
4分钟前
在水一方应助scholar丨崔采纳,获得10
5分钟前
不能随便完成签到,获得积分10
5分钟前
5分钟前
碧蓝香芦完成签到 ,获得积分10
5分钟前
scholar丨崔发布了新的文献求助10
5分钟前
5分钟前
5分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990031
求助须知:如何正确求助?哪些是违规求助? 3532108
关于积分的说明 11256334
捐赠科研通 3270943
什么是DOI,文献DOI怎么找? 1805146
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228