炎症
巨噬细胞
材料科学
脂质代谢
膜
环糊精
新陈代谢
纳米技术
生物化学
免疫学
生物
体外
作者
Nianlian Mou,Xinmei Duan,Kai Qu,Qiao Chen,Zhigui He,Yukui Zhang,Pan Wang,Xian Qin,Lan Zhu,Zhiqiang Han,Chuanwei Li,Yuan Zhong,Wei Wu
标识
DOI:10.1021/acsami.4c11370
摘要
Atherosclerosis is a persistent inflammatory condition of the blood vessels associated with abnormalities in lipid metabolism. Development of biomimetic nanoplatforms provides an effective strategy. Herein, inspired by the peptide CLIKKPF spontaneously coupling to phosphatidylserine (PS) on the inner leaflet of cell membranes specifically, MM@NPs were constructed by macrophage membrane spontaneous encapsulation of cyclodextrin-based nanoparticles modified with the peptide CLIKKPF and loaded with the hydrophobic compound resveratrol. MM@NPs could be specifically phagocytized by the activated endothelium with the overexpressed VCAM-1 for enhancing target delivery into the pathological lesion. Additionally, for the ApoE
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