金黄色葡萄球菌
化学
适体
万古霉素
微生物学
抗生素
肺炎
细菌
分子生物学
医学
生物化学
生物
遗传学
内科学
作者
Shanshan Lin,Yunsi Zheng,Yanlong Xing,Kun Dou,Rui Wang,Hongwang Cui,Rui Wang,Fabiao Yu
出处
期刊:Talanta
[Elsevier BV]
日期:2024-08-08
卷期号:280: 126691-126691
被引量:5
标识
DOI:10.1016/j.talanta.2024.126691
摘要
Staphylococcus aureus (S. aureus) is the most common pathogen in human purulent infections, which can cause local purulent infections, as well as pneumonia, pseudomembranous enteritis, pericarditis, and even systemic infections. The conventional methods including bacteria colony counting, polymerase chain reaction and enzyme-linked immunosorbent assay can't fully meet the requirement of highly sensitive detection of S. aureus due to their own disadvantages. Therefore, it's an urgent need to develop new platform to detect S. aureus in the early infection stage. In this study, a new surface-enhanced Raman scattering (SERS)-based nanoplatform based on dual-recognition of aptamer (Apt) and vancomycin (Van) was developed for the highly sensitive detection of S. aureus. The SERS nanoplatform consisted of two functional parts: aptamer-conjugated Fe
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