亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Identification of HOXB9 to predict prognosis of endometrial cancer based on comprehensive bioinformatics analysis

鉴定(生物学) 子宫内膜癌 医学 生物信息学 计算机科学 计算生物学 肿瘤科 癌症 数据科学 内科学 生物 植物
作者
Yanhua Xu,Mu Zhang,Qin Shi,Xi Cheng,Rong Du,Chenglu Li,Yuquan Zhang
出处
期刊:European Journal of Medical Research [BioMed Central]
卷期号:28 (1) 被引量:2
标识
DOI:10.1186/s40001-022-00979-3
摘要

The HOXB9 gene, which plays a key role in embryonic development, is also involved in the regulation of various human cancers. However, the potential relationship between HOXB9 and endometrial cancer (EC) has not yet been comprehensively analyzed and fully understood.We used multiple bioinformatics tools to explore the role of HOXB9 in EC.The expression of HOXB9 was significantly upregulated in pan-cancer, including EC (P < 0.05). Quantitative real time polymerase chain reaction (qRT-PCR) experiment confirmed the high expression of HOXB9 in EC from clinical samples (P < 0.001). Double validated by Enrichr and Metascape, HOXB9 showed a strong correlation with HOX family, suggesting that HOX family may also involve in the development of EC (P < 0.05). Enrichment analysis revealed HOXB9 is mainly associated with cellular process, developmental process, P53 signaling pathway, etc. At the single-cell level, the clusters of cells ranked were glandular and luminal cells c-24, glandular and luminal cells c-9, endothelial cells c-15, compared with the other cells. At the genetic level, promoter methylation levels of HOXB9 were significantly higher in tumors than in normal tissues. Furthermore, variations of HOXB9 were closely associated with overall survival (OS) and recurrence free survival (RFS) in EC patients (P < 0.05). The agreement between univariate and multivariate Cox regression indicated that the results were more reliable. Stages III and IV, G2 and G3, tumor invasion ≥ 50%, mixed or serous histological type, age > 60 years, and high expression of HOXB9 were risk factors strongly associated with OS in EC patients (P < 0.05). Therefore, six factors were incorporated to construct a nomogram for survival prediction. Finally, we used the Kaplan-Meier (KM) curve, receiver operating characteristic (ROC) curve, and time-dependent ROC to assess predictive power of HOXB9. KM curve showed EC patients overexpressing HOXB9 had a worse OS. AUC of diagnostic ROC was 0.880. AUCs of time-dependent ROC were 0.602, 0.591, and 0.706 for 1-year, 5-year, and 10-year survival probabilities (P < 0.001).Our study provids new insights into the diagnosis and prognosis of HOXB9 in EC and constructs a model that can accurately predict the prognosis of EC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
慕青应助我爱物理采纳,获得10
2秒前
2秒前
充电宝应助霜鸣采纳,获得10
4秒前
5秒前
隐形曼青应助伽拉采纳,获得10
6秒前
hhw完成签到,获得积分10
6秒前
咕噜噜发布了新的文献求助10
8秒前
11秒前
12秒前
研友_qZ6V1Z发布了新的文献求助10
13秒前
涨秋池发布了新的文献求助10
14秒前
燕子完成签到 ,获得积分10
14秒前
14秒前
nicenice发布了新的文献求助10
16秒前
16秒前
yx_cheng应助linkman采纳,获得10
19秒前
20秒前
Bowman发布了新的文献求助30
20秒前
Anthonywll完成签到 ,获得积分10
29秒前
壮观的海豚完成签到 ,获得积分10
32秒前
慕青应助喂喂采纳,获得10
33秒前
zx完成签到 ,获得积分10
35秒前
guozao发布了新的文献求助10
37秒前
咖啡龙完成签到,获得积分20
37秒前
yx_cheng应助linkman采纳,获得10
39秒前
42秒前
ET完成签到,获得积分10
43秒前
完美世界应助towerman采纳,获得10
49秒前
hi_traffic完成签到,获得积分10
54秒前
54秒前
HXY完成签到,获得积分10
56秒前
57秒前
57秒前
1分钟前
领导范儿应助linkman采纳,获得30
1分钟前
eric888应助guozao采纳,获得150
1分钟前
1分钟前
小马甲应助科研通管家采纳,获得10
1分钟前
towerman完成签到,获得积分10
1分钟前
towerman发布了新的文献求助10
1分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990012
求助须知:如何正确求助?哪些是违规求助? 3532049
关于积分的说明 11256153
捐赠科研通 3270925
什么是DOI,文献DOI怎么找? 1805123
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809216