诱导多能干细胞
组织工程
转化研究
再生医学
干细胞
医学
生物信息学
计算机科学
生物
生物医学工程
病理
胚胎干细胞
遗传学
生物化学
基因
作者
Sarah E Motta,Marcy Martin,Eric K N Gähwiler,Valery L Visser,Polina Zaytseva,Arian Ehterami,Simon P Hoerstrup,Maximilian Y Emmert
标识
DOI:10.1093/stcltm/szad002
摘要
Abstract Cardiovascular disease is a major cause of morbidity and mortality worldwide and, to date, the clinically available prostheses still present several limitations. The design of next-generation regenerative replacements either based on cellular or extracellular matrix technologies can address these shortcomings. Therefore, tissue engineered constructs could potentially become a promising alterative to the current therapeutic options for patients with cardiovascular diseases. In this review, we selectively present an overview of the current tissue engineering tools such as induced pluripotent stem cells, biomimetic materials, computational modeling, and additive manufacturing technologies, with a focus on their application to translational cardiovascular therapies. We discuss how these advanced technologies can help the development of biomimetic tissue engineered constructs and we finally summarize the latest clinical evidence for their use, and their potential therapeutic outcome.
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