SNi公司
神经病理性疼痛
神经损伤
痛觉超敏
医学
痛觉过敏
周围神经损伤
麻醉
背根神经节
脊神经
神经科学
伤害
背
心理学
解剖
坐骨神经
生物
内科学
受体
生物化学
水解
酸水解
作者
Marie Pertin,Romain‐Daniel Gosselin,Isabelle Décosterd
出处
期刊:Methods in molecular biology
日期:2012-01-01
卷期号:: 205-212
被引量:51
标识
DOI:10.1007/978-1-61779-561-9_15
摘要
The spared nerve injury (SNI) model mimics human neuropathic pain related to peripheral nerve injury and is based upon an invasive but simple surgical procedure. Since its first description in 2000, it has displayed a remarkable development. It produces a robust, reliable and long-lasting neuropathic pain-like behaviour (allodynia and hyperalgesia) as well as the possibility of studying both injured and non-injured neuronal populations in the same spinal ganglion. Besides, variants of the SNI model have been developed in rats, mice and neonatal/young rodents, resulting in several possible angles of analysis. Therefore, the purpose of this chapter is to provide a detailed guidance regarding the SNI model and its variants, highlighting its surgical and behavioural testing specificities.
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