亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Volatile organic compounds in exhaled breath of patients with COPD ± lung cancer and their correlation with FEV1-values

慢性阻塞性肺病 医学 肺癌 呼出气冷凝液 呼出的空气 内科学 胃肠病学 分析物 色谱法 毒理 哮喘 化学 生物
作者
Michael Westhoff,P Litterst,H Sommer,Betram Bödecker,J. I. Baumbach
出处
期刊:European Respiratory Journal 卷期号:44: 987-
摘要

Introduction Ion mobility spectrometry (MCC/IMS) is currently evaluated for exhaled breath analysis in different pulmonary diseases. The relevance of different specific volatile organic compounds (VOC) and their potential relations to FEV1 still remain unknown. We wondered if patients with COPD ± lung cancer exhale different VOCs and if there is a relation to FEV1 resp. FEV1/VC. Methods In 61 patients with COPD and lung cancer, 23 with COPD and 32 healthy controls exhaled breath was analysed with an IMS coupled to a multi capillary column (MCC/IMS). Discrimination between the subgroups was made by a decision-tree-model. Results 102 different peaks were found. 29 showed a 99 % significance level, including 2-Methylfurane, 2-Methylpentane, 1-Butanole, Butanal, Cyclohexanole, Propanal, 1-Hexanole, n-Nona, 2-Heptanole, 3-Pentanone, Phenylacetylene, 2-Butanone and Isoprene. A decision tree starting with 2-Methylpentane showed the decision power in two steps. Sensitivity of 100 % and specificity of 97 % was calculated. 3-Pentanone Dimer and 1-Hexanole differentiated the LC/COPD group from healthy control, with a specificity of 94 %. Finally, the groups COPD, LC/COPD and healthy control were differenciated using a 2-step decision tree starting with 1-Hexanole and Acetone. Correlations between analyte concentrations and FEV1 were found for the following analytes: increasing e.g. Ammonia, decreasing e.g. 1-Octanole. Conclusions Some VOCs in exhaled air of patients with COPD ± lung cancer and healthy controls allowed the separation of these group. Ffunctional impairment seems to influence the concentration of some analytes; this has to be taken into account in further analysis.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Hung发布了新的文献求助10
1秒前
8秒前
Lyncon完成签到,获得积分10
12秒前
Milton_z完成签到 ,获得积分0
22秒前
Hung完成签到,获得积分10
25秒前
tingyeh完成签到,获得积分10
31秒前
32秒前
两个我完成签到 ,获得积分10
39秒前
45秒前
55秒前
57秒前
务实书包完成签到,获得积分10
1分钟前
1分钟前
1分钟前
1分钟前
英姑应助科研通管家采纳,获得10
1分钟前
打打应助科研通管家采纳,获得10
1分钟前
1分钟前
24124f发布了新的文献求助10
1分钟前
1分钟前
2分钟前
2分钟前
大闲鱼铭一完成签到 ,获得积分10
2分钟前
干净涵梅发布了新的文献求助10
2分钟前
舒适的藏花完成签到 ,获得积分10
2分钟前
2分钟前
boogie发布了新的文献求助10
2分钟前
testmanfuxk完成签到,获得积分10
2分钟前
2分钟前
polelight发布了新的文献求助30
2分钟前
boogie完成签到,获得积分20
2分钟前
wdy111应助云缘之芒采纳,获得50
2分钟前
2分钟前
小付发布了新的文献求助10
2分钟前
2分钟前
3分钟前
红橙黄绿蓝靛紫111完成签到,获得积分10
3分钟前
cy0824完成签到 ,获得积分10
3分钟前
yyy完成签到 ,获得积分10
3分钟前
SciGPT应助科研通管家采纳,获得10
3分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990049
求助须知:如何正确求助?哪些是违规求助? 3532108
关于积分的说明 11256354
捐赠科研通 3270976
什么是DOI,文献DOI怎么找? 1805166
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228