摘要
articleOsteocalcin and matrix Gla protein: vitamin K-dependent proteins in boneP. V. Hauschka, J. B. Lian, D. E. Cole, and C. M. GundbergP. V. HauschkaDepartment of Oral Biology, Harvard School of Dental Medicine, Boston,Massachusetts., J. B. LianDepartment of Oral Biology, Harvard School of Dental Medicine, Boston,Massachusetts., D. E. ColeDepartment of Oral Biology, Harvard School of Dental Medicine, Boston,Massachusetts., and C. M. GundbergDepartment of Oral Biology, Harvard School of Dental Medicine, Boston,Massachusetts.Published Online:01 Jul 1989https://doi.org/10.1152/physrev.1989.69.3.990MoreSectionsPDF (9 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmailWeChat Previous Back to Top Download PDF FiguresReferencesRelatedInformationCited ByParacrine and endocrine actions of bone—the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts24 May 2018 | Bone Research, Vol. 6, No. 1Potential Protective Effect of Osteocalcin in Middle-Aged Men with Erectile Dysfunction: Evidence from the FAMHES Project30 April 2018 | Scientific Reports, Vol. 8, No. 1First evidence of octacalcium [email protected] nanocomplex as skeletal bone component directing collagen triple–helix nanofibril mineralization12 September 2018 | Scientific Reports, Vol. 8, No. 1Molecular bases of the crosstalk between bone and muscleBone, Vol. 115Employing different types of phytoestrogens improve bone mineralization in bisphenol A stimulated osteoblastLife Sciences, Vol. 210Responses to spaceflight of mouse mandibular bone and teethArchives of Oral Biology, Vol. 93Influence of weight gain on the modulation of wound healing following tooth extractionBone, Vol. 114Association of Vitamin K Status Combined With Vitamin D Status and Lower-Extremity Function: A Prospective Analysis of Two Knee Osteoarthritis Cohorts29 May 2018 | Arthritis Care & Research, Vol. 70, No. 8Purification and structural characterization of water-soluble menaquinone-7 produced by Bacillus subtilis natto31 July 2018 | Journal of Food Biochemistry, Vol. 62The Effects of Chemical Castration with Degarelix on Bone Turnover: Densitometric and Biomechanics Bone Properties of Male Rats2 July 2018 | International Journal of Endocrinology and Metabolism, Vol. 16, No. 3Mycobacterial infection influences bone biomarker levels in patients with Crohn’s diseaseCanadian Journal of Physiology and Pharmacology, Vol. 96, No. 7Undercarboxylated Osteocalcin: Experimental and Human Evidence for a Role in Glucose Homeostasis and Muscle Regulation of Insulin Sensitivity29 June 2018 | Nutrients, Vol. 10, No. 7Vitamin K and Bone Metabolism: A Review of the Latest Evidence in Preclinical StudiesBioMed Research International, Vol. 2018Vitamin Status and Mineralized Tissue Development21 April 2018 | Current Oral Health Reports, Vol. 5, No. 2Thin bones: Vitamin D and calcium handling after bariatric surgeryBone Reports, Vol. 8Putative biomarkers of vedolizumab resistance and underlying inflammatory pathways involved in IBD31 May 2018 | BMJ Open Gastroenterology, Vol. 5, No. 1Vitamin D in Vascular Calcification: A Double-Edged Sword?22 May 2018 | Nutrients, Vol. 10, No. 5The effect of weight loss on body composition, serum bone markers, and adipokines in prepubertal obese children after 1-year intervention1 December 2017 | Endocrine Research, Vol. 43, No. 2Matrix Gla protein negatively regulates calcification of human aortic valve interstitial cells isolated from calcified aortic valvesJournal of Pharmacological Sciences, Vol. 136, No. 4Effect of buffalo casein-derived novel bioactive peptides on osteoblast differentiation21 November 2016 | European Journal of Nutrition, Vol. 57, No. 2Cardiovascular Autonomic Dysfunction: Link Between Multiple Sclerosis Osteoporosis and Neurodegeneration10 February 2018 | NeuroMolecular Medicine, Vol. 20, No. 1Relationship between impaired forearm endothelial function and osteoporosis in Tunisian postmenopausal women: Serum lipids or others factors?Journal of Indian College of Cardiology, Vol. 8, No. 1Association of body mass index and waist circumference with osteocalcin and C-terminal telopeptide in Iranian elderly: results from a cross-sectional study23 February 2018 | Journal of Bone and Mineral Metabolism, Vol. 26Bioanalytical Method Based on Extended-Gate Field-Effect Transistor Modified by Self-Assembled Monolayer5 January 2018 | International Journal of Automation Technology, Vol. 12, No. 1Multiple Coagulation Factor Deficiency26 July 2018Altered Ethanol Consumption in Osteocalcin Null Mutant Mice29 August 2017 | Cellular and Molecular Neurobiology, Vol. 38, No. 1The Cross Talk Between the Central Nervous System, Bone, and Energy MetabolismIntestinal Absorption of Vitamin K: Cellular and Molecular MechanismsCalcium Homeostasis and Eggshell Biomineralization in Female ChickenOsteocalcin facilitates calcium phosphate ion complex growth as revealed by free energy calculation1 January 2018 | Physical Chemistry Chemical Physics, Vol. 20, No. 18Two Transcripts of FBXO5 Promote Migration and Osteogenic Differentiation of Human Periodontal Ligament Mesenchymal Stem CellsBioMed Research International, Vol. 2018Detection of ostecalcin in gingival crevicular fluid in a group of orthodontic patientsJournal of International Society of Preventive and Community Dentistry, Vol. 8, No. 2Evaluation of twelve vibration regimes applied to improve spine properties in ovariectomized ratsBone Reports, Vol. 7Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal SystemsKazuo Okamoto, Tomoki Nakashima, Masahiro Shinohara, Takako Negishi-Koga, Noriko Komatsu, Asuka Terashima, Shinichiro Sawa, Takeshi Nitta, and Hiroshi Takayanagi16 August 2017 | Physiological Reviews, Vol. 97, No. 4Comparison of Decellularized Cow and Human Bone for Engineering Bone Grafts with human iPS cells21 August 2018 | Tissue Engineering Part AAnalysis of serum undercarboxylated osteocalcin level in rats with type 2 diabetes mellitus and the correlation with cognitive impairment25 July 2017 | Experimental and Therapeutic Medicine, Vol. 14, No. 3Orientation and conformation of osteocalcin adsorbed onto calcium phosphate and silica surfacesBiointerphases, Vol. 12, No. 2Bone Cell Bioenergetics and Skeletal Energy HomeostasisRyan C. Riddle and Thomas L. Clemens15 February 2017 | Physiological Reviews, Vol. 97, No. 2Tgfbr2 is required in osterix expressing cells for postnatal skeletal developmentBone, Vol. 97Resveratrol suppresses thyroid hormone-induced osteocalcin synthesis in osteoblasts28 June 2017 | Molecular Medicine Reports, Vol. 16, No. 3Sequencing and bioinformatics analysis of the differentially expressed genes in herniated discs with or without calcification7 December 2016 | International Journal of Molecular Medicine, Vol. 39, No. 1Acute calcium kinetics in haemodialysis patients26 October 2016 | European Journal of Clinical Investigation, Vol. 46, No. 12Attenuation by incretins of thyroid hormone-stimulated osteocalcin synthesis in osteoblasts1 November 2016 | Biomedical Reports, Vol. 5, No. 6Molecular profiling of a simple rat model of open tibial fractures with hematoma and periosteum disruption29 September 2016 | Experimental and Therapeutic Medicine, Vol. 12, No. 5Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid TherapyKerstin Hartmann, Mascha Koenen, Sebastian Schauer, Stephanie Wittig-Blaich, Mubashir Ahmad, Ulrike Baschant, and Jan P. Tuckermann3 February 2016 | Physiological Reviews, Vol. 96, No. 2Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma MembraneEdouard M. Bevers and Patrick L. Williamson2 March 2016 | Physiological Reviews, Vol. 96, No. 2Recapitulating cranial osteogenesis with neural crest cells in 3-D microenvironmentsActa Biomaterialia, Vol. 31Lower uncarboxylated osteocalcin and higher sclerostin levels are significantly associated with coronary artery diseaseBone, Vol. 83Biomineral/Agarose Composite Gels Enhance Proliferation of Mesenchymal Stem Cells with Osteogenic Capability23 June 2015 | International Journal of Molecular Sciences, Vol. 16, No. 12NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy18 February 2015 | Science Translational Medicine, Vol. 7, No. 275Vitamin K2 Therapy for Postmenopausal Osteoporosis16 May 2014 | Nutrients, Vol. 6, No. 5El hueso como órgano endocrino y su conexión con el metabolismo energéticoImplications of autophagy for vascular smooth muscle cell function and plasticityFree Radical Biology and Medicine, Vol. 65Short Periods of Cyclic Mechanical Strain Enhance Triple-Supplement Directed Osteogenesis and Bone Nodule Formation by Human Embryonic Stem Cells In VitroTissue Engineering Part A, Vol. 19, No. 19-20Menaquinones, Bacteria, and the Food Supply: The Relevance of Dairy and Fermented Food Products to Vitamin K Requirements8 July 2013 | Advances in Nutrition, Vol. 4, No. 4AMP-activated protein kinase regulates thyroid hormone-stimulated osteocalcin synthesis in osteoblasts15 April 2013 | International Journal of Molecular Medicine, Vol. 31, No. 6Human Very Small Embryonic-Like Cells Generate Skeletal Structures, In VivoStem Cells and Development, Vol. 22, No. 4Polyphenols, isothiocyanates, and carotenoid derivatives enhance estrogenic activity in bone cells but inhibit it in breast cancer cellsAnna Veprik, Marina Khanin, Karin Linnewiel-Hermoni, Michael Danilenko, Joseph Levy, and Yoav Sharoni1 October 2012 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 303, No. 7Effect of Enamel Matrix Derivative and of Proline-Rich Synthetic Peptides on the Differentiation of Human Mesenchymal Stem Cells Toward the Osteogenic LineageTissue Engineering Part A, Vol. 18, No. 11-12Vitamin K-Dependent Carboxylation of Osteocalcin: Friend or Foe?2 March 2012 | Advances in Nutrition, Vol. 3, No. 2Bone Cell BiologyBone Matrix and MineralizationMechanism of Mineralization of Collagen-Based Connective Tissues1 June 2010Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?19 August 2009 | The American Journal of Clinical Nutrition, Vol. 90, No. 4Osteocalcin Secretion as an Early Marker of In Vitro Osteogenic Differentiation of Rat Mesenchymal Stem CellsTissue Engineering Part C: Methods, Vol. 15, No. 2Connexin43 Potentiates Osteoblast Responsiveness to Fibroblast Growth Factor 2 via a Protein Kinase C-Delta/Runx2–dependent MechanismMolecular Biology of the Cell, Vol. 20, No. 11Biological Basis of Bone Formation, Remodeling, and Repair—Part II: Extracellular MatrixTissue Engineering Part B: Reviews, Vol. 14, No. 3Bone Health and Osteoporosis: The Role of Vitamin K and Potential Antagonism by Anticoagulants6 January 2017 | Nutrition in Clinical Practice, Vol. 22, No. 5A skeleton key to metabolismNature Medicine, Vol. 13, No. 9Calcified Matrix Production by SAOS-2 Cells Inside a Polyurethane Porous Scaffold, Using a Perfusion BioreactorTissue Engineering, Vol. 11, No. 5-6Processing and Transport of Matrix γ-Carboxyglutamic Acid Protein and Bone Morphogenetic Protein-2 in Cultured Human Vascular Smooth Muscle Cells27 July 2004 | Journal of Biological Chemistry, Vol. 279, No. 41New data on bone matrix and its proteinsComptes Rendus Palevol, Vol. 3, No. 6-7Familial multiple coagulation factor deficiencies: new biologic insight from rare genetic bleeding disorders26 August 2004 | Journal of Thrombosis and Haemostasis, Vol. 2, No. 9Relation of low bone mineral density and carotid atherosclerosis in postmenopausal womenThe American Journal of Cardiology, Vol. 94, No. 2Matrix-mediated retention of osteogenic differentiation potential by human adult bone marrow stromal cells during ex vivo expansionBiomaterials, Vol. 25, No. 16Mechanism of acid-induced bone resorptionCurrent Opinion in Nephrology and Hypertension, Vol. 13, No. 4The Inhibitory Effect of Calumenin on the Vitamin K-dependent γ-Carboxylation SystemJournal of Biological Chemistry, Vol. 279, No. 24Release of Intact and Fragmented Osteocalcin Molecules from Bone Matrix during Bone Resorption in Vitro16 February 2004 | Journal of Biological Chemistry, Vol. 279, No. 18Bone protects proteins over thousands of years: Extraction, analysis, and interpretation of extracellular matrix proteins in archeological skeletal remains1 January 2003 | American Journal of Physical Anthropology, Vol. 123, No. 1Primitive adult hematopoietic stem cells can function as osteoblast precursors12 December 2003 | Proceedings of the National Academy of Sciences, Vol. 100, No. 26Functionally graded materials for biomedical applicationsMaterials Science and Engineering: A, Vol. 362, No. 1-2Bone recognition mechanism of porcine osteocalcin from crystal structure30 October 2003 | Nature, Vol. 425, No. 6961Markers of Osteoblast Differentiation in Fusing and Nonfusing Cranial SuturesPlastic and Reconstructive Surgery, Vol. 112, No. 5Nachweis der Osteokalzinexpression osteoblastärer Zellen mandibulären Ursprungs, wachsend auf Biomaterialien, mittels RT-PCR und SDS-PAGE/Western Blotting12 September 2003 | Mund-, Kiefer- und Gesichtschirurgie, Vol. 7, No. 5Species comparison of vitamin K1 2,3-epoxide reductase activity in vitro: kinetics and warfarin inhibitionToxicology, Vol. 189, No. 3Structural Basis of Calcification Inhibition by α 2 -HS Glycoprotein/Fetuin-A29 January 2003 | Journal of Biological Chemistry, Vol. 278, No. 15Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional studyThe Lancet, Vol. 361, No. 9360Nutritional interventions related to bone turnover in European space missions and simulation modelsNutrition, Vol. 18, No. 10Functions of Transforming Growth Factor-β Family Type I Receptors and Smad Proteins in the Hypertrophic Maturation and Osteoblastic Differentiation of Chondrocytes24 June 2002 | Journal of Biological Chemistry, Vol. 277, No. 37Vitamin D Gene RegulationBiochemical Markers of Bone MetabolismSequence preservation of osteocalcin protein and mitochondrial DNA in bison bones older than 55 kaGeology, Vol. 30, No. 12A Mouse Model of Mandibular Osteotomy HealingJournal of Craniofacial Surgery, Vol. 12, No. 5Distraction Osteogenesis of the Craniofacial SkeletonPlastic and Reconstructive Surgery, Vol. 107, No. 7Rat Mandibular Distraction Osteogenesis: Part III. Gradual Distraction versus Acute LengtheningPlastic and Reconstructive Surgery, Vol. 107, No. 2Repeated immobilization stress reduces rat vertebral bone growth and osteocalcinPatricia Patterson-Buckendahl, Milan Rusnák, Koki Fukuhara, and Richard Kvetnan̆ský1 January 2001 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 280, No. 1The Biochemistry of BoneNutrition and Risk for OsteoporosisOral Anticoagulants: Mechanism of Action, Clinical Effectiveness, and Optimal Therapeutic RangeChest, Vol. 119, No. 1Bioactive materials to control cell cycle13 October 2016 | Materials Research Innovations, Vol. 3, No. 6Biochemical Markers of Bone FormationClinics in Laboratory Medicine, Vol. 20, No. 3In vitro metabolic and respiratory acidosis selectively inhibit osteoblastic matrix gene expressionKevin K. Frick, and David A. Bushinsky1 November 1999 | American Journal of Physiology-Renal Physiology, Vol. 277, No. 5Blood Circulation as Source for Osteopontin in Acellular Extrinsic Fiber Cementum and Other Mineralizing Tissues8 November 2016 | Journal of Dental Research, Vol. 78, No. 11Prevalence of vitamin K deficiency in cystic fibrosisThe American Journal of Clinical Nutrition, Vol. 70, No. 3Force-induced Rapid Changes in Cell Fate at Midpalatal Suture Cartilage of Growing Rats8 November 2016 | Journal of Dental Research, Vol. 78, No. 9Basic Principles and Clinical Applications of Biochemical Markers of Bone MetabolismJournal of Clinical Densitometry, Vol. 2, No. 3Rat Mandibular Distraction Osteogenesis: II. Molecular Analysis of Transforming Growth Factor Beta-1 and Osteocalcin Gene ExpressionPlastic and Reconstructive Surgery, Vol. 103, No. 2The Effect of Diet on Blood Vitamin K Status and Urinary Mineral Excretion Assessed by a Food Questionnaire1 August 2016 | Nutrition and Health, Vol. 13, No. 1Chronic metabolic acidosis reversibly inhibits extracellular matrix gene expression in mouse osteoblastsKevin K. Frick, and David A. Bushinsky1 November 1998 | American Journal of Physiology-Renal Physiology, Vol. 275, No. 5Bacteria Inhibit Biosynthesis of Bone Matrix Proteins in Human OsteoblastsClinical Orthopaedics and Related Research, Vol. 346Effect of endurance training on postexercise parathyroid hormone levels in elderly menMedicine & Science in Sports & Exercise, Vol. 29, No. 9Glucocorticoid-Dependent Transcriptional Repression of the Osteocalcin Gene by Competitive Binding at the TATA BoxDNA and Cell Biology, Vol. 16, No. 8Structural and functional aspects of calcium binding in extracellular matrix proteinsMatrix Biology, Vol. 15, No. 8-9[33] Purification of warfarin-sensitive vitamin K epoxide reductaseDepressed Osteoblast Activity and Increased Osteocyte Necrosis after Closed Bone Fracture and Hemorrhagic ShockThe Journal of Trauma: Injury, Infection, and Critical Care, Vol. 41, No. 4Mechanisms of initiating calcification. ATP-stimulated Ca- and Pi-depositing activity of isolated matrix vesiclesInternational Journal of Biochemistry, Vol. 26, No. 12Estimation of age at death based on aspartic acid racemization in noncollagenous bone proteinsForensic Science International, Vol. 69, No. 2Normal long bone growth and development in type X collagen-null mice1 October 1994 | Nature Genetics, Vol. 8, No. 2The displacement of calcium from osteocalcin at submicromolar concentrations of free leadBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1226, No. 2Bone Cell Expression on Titanium Surfaces is Altered by Sterilization Treatments8 November 2016 | Journal of Dental Research, Vol. 73, No. 5Coronary arterial calcification as an active process: A new perspective on an old problemCalcified Tissue International, Vol. 54, No. 3Osteoporosis: Pathophysiology, prevention, diagnosis, and treatmentDisease-a-Month, Vol. 39, No. 11Concepts of Osteoblast Growth and Differentiation: Basis for Modulation of Bone Cell Development and Tissue Formation1 December 2016 | Critical Reviews in Oral Biology & Medicine, Vol. 3, No. 3Radiocarbon Dating of Bone Osteocalcin: Isolating and Characterizing a Non-Collagen Protein18 July 2016 | Radiocarbon, Vol. 34, No. 03Tissue distribution of selective warfarin binding sites in the ratBiochemical Pharmacology, Vol. 42, No. 11Comparison of bone collagen and osteocalcin for determination of radiocarbon ages and paleodietary reconstructionEarth and Planetary Science Letters, Vol. 107, No. 2Effects of estrogen and tamoxifen on serum osteocalcin levels in ovariectomized ratsBone and Mineral, Vol. 14, No. 3Binding of serum osteocalcin to hydroxyapatite in Paget's disease of boneBone and Mineral, Vol. 14, No. 1The Role of Extracellular Matrix Components in Dentin Mineralization1 December 2016 | Critical Reviews in Oral Biology & Medicine, Vol. 2, No. 3The Concept of Osseointegration and Bone Matrix Expression1 December 2016 | Critical Reviews in Oral Biology & Medicine, Vol. 2, No. 1Phenytoin affects osteocalcin secretion from osteoblastic rat osteosarcoma 172.8 cells in cultureBone, Vol. 11, No. 5 More from this issue > Volume 69Issue 3July 1989Pages 990-1047 Copyright & PermissionsCopyright © 1989 the American Physiological Societyhttps://doi.org/10.1152/physrev.1989.69.3.990PubMed2664828History Published online 1 July 1989 Published in print 1 July 1989 Metrics