Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTMultiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?Vincenzo Alterio†, Anna Di Fiore†, Katia D'Ambrosio†, Claudiu T. Supuran*‡, and Giuseppina De Simone*†View Author Information† Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Napoli, Italy‡ Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, I-50019 Sesto Fiorentino, Firenze, Italy*Phone: +39-055-4573005 (C.T.S.); +39-081-2534579 (G.D.S.). Fax: +39-055-4573385 (C.T.S.); +39-081-2536642 (G.D.S.). E-mail: [email protected] (C.T.S.); [email protected] (G.D.S.).Cite this: Chem. Rev. 2012, 112, 8, 4421–4468Publication Date (Web):May 18, 2012Publication History Received18 May 2011Published online18 May 2012Published inissue 8 August 2012https://pubs.acs.org/doi/10.1021/cr200176rhttps://doi.org/10.1021/cr200176rreview-articleACS PublicationsCopyright © 2012 American Chemical SocietyRequest reuse permissionsArticle Views8667Altmetric-Citations992LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Inhibitors,Ions,Molecules,Peptides and proteins,Sulfones Get e-Alerts