Silk Protein Lithography as a Route to Fabricate Sericin Microarchitectures

Photolithographic fabrication via a "silk sericin photoresist" is used to form precise protein microstructures directly and rapidly on a variety of substrates. High-resolution and fidelity architectures in two and three dimensions with line widths down to 1 μm are formed. Photo-crosslinked protein structures provide structural iridescence and guide cell adhesion with precise spatial control.