咖啡因
癌变
多酚
红茶
绿茶
口服
化学
药理学
抗癌原
抑制性突触后电位
传统医学
医学
食品科学
生物化学
抗氧化剂
内科学
基因
作者
Mou Tuan Huang,Junshan Xie,Zhi Yuan Wang,Chi‐Tang Ho,You-Rong Lou,Chung Xiou Wang,Gordon C. Hard,Allan H. Conney
出处
期刊:PubMed
日期:1997-07-01
卷期号:57 (13): 2623-9
被引量:58
摘要
Oral administration of green or black tea inhibited UVB light-induced complete carcinogenesis in the skin of SKH-1 mice. Green tea was a more effective inhibitor than black tea. Oral administration of decaffeinated green or black tea resulted in substantially less inhibitory activity than did administration of the regular teas, and in one experiment, administration of a high-dose level of the decaffeinated teas enhanced the tumorigenic effect of UVB. Oral administration of caffeine alone had a substantial inhibitory effect on UVB-induced carcinogenesis, and adding caffeine to the decaffeinated teas restored the inhibitory effects of these teas on UVB-induced carcinogenesis. In additional studies, topical application of a green tea polyphenol fraction after each UVB application inhibited UVB-induced tumorigenesis. The results indicate that caffeine contributes in an important way to the inhibitory effects of green and black tea on UVB-induced complete carcinogenesis.
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