开胃菜
链霉菌
突变体
生物合成
拉伤
环己烯
化学
生物化学
立体化学
生物
细菌
遗传学
基因
食品科学
解剖
催化作用
作者
Yeon Hee Ban,Jong Hyun Lee,Gyo Rim Gu,Boram Lee,SangJoon Mo,Ho Jeong Kwon,Yeo Joon Yoon
摘要
A FK506 analogue containing a non-natural starter unit was obtained through mutasynthesis by feeding cultures of Streptomyces sp. KCTC 11604BP fkbO deletion mutant with 3-cyclohexene-1-carboxylic acid. The structure of the new compound, 32-dehydroxy-FK506, and its biological activities were determined.
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