多巴胺转运体
自闭症
多巴胺
血清素转运体
多巴胺能
心理学
再摄取
神经科学
5-羟色胺能
血清素
内科学
精神科
医学
受体
作者
Kazuhiko Nakamura,Yoshimoto Sekine,Yasuomi Ouchi,Masatsugu Tsujii,Etsuji Yoshikawa,Masami Futatsubashi,Kenji J. Tsuchiya,Genichi Sugihara,Yasuhide Iwata,Katsuaki Suzuki,Hideo Matsuzaki,Eri Segi‐Nishida,Toshiro Sugiyama,Nori Takei,Norio Mori
出处
期刊:Archives of General Psychiatry
[American Medical Association]
日期:2010-01-01
卷期号:67 (1): 59-59
被引量:332
标识
DOI:10.1001/archgenpsychiatry.2009.137
摘要
Context
Autism is a neurodevelopmental disorder that is characterized by repetitive and/or obsessive interests and behavior and by deficits in sociability and communication. Although its neurobiological underpinnings are postulated to lie in abnormalities of the serotoninergic and dopaminergic systems, the details remain unknown. Objective
To determine the occurrence of changes in the binding of serotonin and dopamine transporters, which are highly selective markers for their respective neuronal systems. Design
Using positron emission tomography, we measured the binding of brain serotonin and dopamine transporters in each individual with the radioligands carbon 11 (11C)–labeledtrans-1,2,3,5,6,10-β-hexahydro-6-[4-(methylthio)phenyl]pyrrolo-[2,1-a]isoquinoline ([11C](+)McN-5652) and 2β-carbomethoxy-3-β-(4-fluorophenyl)tropane ([11C]WIN-35,428), respectively. Statistical parametric mapping was used for between-subject analysis and within-subject correlation analysis with respect to clinical variables. Setting
Participants recruited from the community. Participants
Twenty men (age range, 18-26 years; mean [SD] IQ, 99.3 [18.1]) with autism and 20 age- and IQ-matched control subjects. Results
Serotonin transporter binding was significantly lower throughout the brain in autistic individuals compared with controls (P < .05, corrected). Specifically, the reduction in the anterior and posterior cingulate cortices was associated with the impairment of social cognition in the autistic subjects (P < .05, corrected). A significant correlation was also found between repetitive and/or obsessive behavior and interests and the reduction of serotonin transporter binding in the thalamus (P < .05, corrected). In contrast, the dopamine transporter binding was significantly higher in the orbitofrontal cortex of the autistic group (P < .05, corrected in voxelwise analysis). In the orbitofrontal cortex, the dopamine transporter binding was significantly inversely correlated with serotonin transporter binding (r = −0.61;P = .004). Conclusions
The brains of autistic individuals have abnormalities in both serotonin transporter and dopamine transporter binding. The present findings indicate that the gross abnormalities in these neurotransmitter systems may underpin the neurophysiologic mechanism of autism. Our sample was not characteristic or representative of a typical sample of adults with autism in the community.
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