A Nomogram to Predict the Duration of Drainage in Patients With Penile Cancer Treated With Inguinal Lymph Node Dissection

No AccessJournal of UrologyAdult Urology1 Jan 2012A Nomogram to Predict the Duration of Drainage in Patients With Penile Cancer Treated With Inguinal Lymph Node Dissection Jia-Quan Zhou, Yao Zhu, Ding-Wei Ye, Xu-Dong Yao, Shi-Lin Zhang, Bo Dai, Hai-Liang Zhang, and Yi-Jun Shen Jia-Quan ZhouJia-Quan Zhou , Yao ZhuYao Zhu , Ding-Wei YeDing-Wei Ye , Xu-Dong YaoXu-Dong Yao , Shi-Lin ZhangShi-Lin Zhang , Bo DaiBo Dai , Hai-Liang ZhangHai-Liang Zhang , and Yi-Jun ShenYi-Jun Shen View All Author Informationhttps://doi.org/10.1016/j.juro.2011.09.024AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We developed a nomogram to predict the duration of drainage in patients with penile cancer treated with inguinal lymph node dissection. Materials and Methods: A total of 111 groin basins in 56 patients who underwent radical inguinal lymph node dissection for penile cancer were retrospectively assessed. We retrieved the clinicopathological factors from the medical records including age, body mass index, albumin, smoking history, hypertension, diabetes, preoperative radiotherapy/chemotherapy, palpable lymph nodes, previous lymph node biopsy, total number of resected lymph nodes and ratio of positive lymph nodes. The criterion of drain removal was total drain output of 50 ml or less per day for 2 days starting from postoperative day 3. A multivariate Cox proportional hazards model was used to explore the risk factors of drainage duration and variable selection was performed according to Akaike's information criteria. A nomogram was built based on regression coefficients and internally validated with 200 bootstrap resamples. Results: Median postoperative drainage duration was 7 days. The prediction model using pretreatment factors showed a concordance index of 0.55. With the addition of lymph node related variables a second model was constructed which produced a better concordance index (0.65) and good calibration. On multivariate analysis young age, high body mass index, total number of resected lymph nodes and ratio of positive lymph nodes were independent predictors of prolonged lymphatic drainage. Conclusions: On the basis of readily obtained clinicopathological variables we developed a nomogram to predict the duration of lymphatic drainage which, if externally validated, could be helpful for patient consultation, treatment decision making and clinical trial design. References 1 : Penile carcinoma: a challenge for the developing world. Lancet Oncol2004; 5: 240. Google Scholar 2 : Lymphadenectomy in the surgical management of penile cancer. Eur Urol2009; 55: 1075. Google Scholar 3 : Contemporary inguinal lymph node dissection: minimizing complications. World J Urol2009; 27: 205. 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More articles by this author Yao Zhu Equal study contribution. More articles by this author Ding-Wei Ye More articles by this author Xu-Dong Yao More articles by this author Shi-Lin Zhang More articles by this author Bo Dai More articles by this author Hai-Liang Zhang More articles by this author Yi-Jun Shen More articles by this author Expand All Advertisement PDF downloadLoading ...