Lung Protective Strategies of Ventilation in the Neonate: What Are They?

Commentary| January 01 2000 Lung Protective Strategies of Ventilation in the Neonate: What Are They? Reese H. Clark, MD; Reese H. Clark, MD Search for other works by this author on: This Site PubMed Google Scholar Arthur S. Slutsky, MD; Arthur S. Slutsky, MD Search for other works by this author on: This Site PubMed Google Scholar Dale R. Gerstmann, MD Dale R. Gerstmann, MD Search for other works by this author on: This Site PubMed Google Scholar Reprint requests to (R.H.C.) Pediatrix Medical Group, 1455 North Park Dr, Weston, FL 33326. E-mail: reese Pediatrics (2000) 105 (1): 112–114. https://doi.org/10.1542/peds.105.1.112 Article history Received: August 23 1999 Accepted: August 23 1999 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Reese H. Clark, Arthur S. Slutsky, Dale R. Gerstmann; Lung Protective Strategies of Ventilation in the Neonate: What Are They?. Pediatrics January 2000; 105 (1): 112–114. 10.1542/peds.105.1.112 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search toolbar search search input Search input auto suggest filter your search All PublicationsAll JournalsPediatricsHospital PediatricsPediatrics In ReviewNeoReviewsAAP Grand RoundsAAP NewsAll AAP Sites Search Advanced Search Topics: environmental air flow, lung, lung injury, ventilator-associated, respiration, tidal volume, lung injuries, positive end-expiratory pressure, pulmonary gas exchange In the July 1999 issue of theJournal of the American Medical Association, Dr Leonard Hudson proclaims that "the concept of ventilator-induced lung injury (VILI) has come of age."1 His comments were derived from a report by Ranieri et al2 which shows that a "lung-protective strategy" of respiratory support reduces cytokine levels in both the bronchoalveolar lavage fluid and serum of adult patients with acute respiratory distress syndrome (ARDS). Dr Hudson's enthusiasm is increased by the recent press release from the National Institutes of Health (NIH) ARDS Network Study, reporting positive results of a study evaluating a "lung-protective strategy" in >800 adults with ARDS. The NIH study was stopped early, when the safety monitoring committee noted "25% fewer deaths" among patients receiving small (6 mL/kg) rather than large (12 mL/kg) tidal volumes to support gas exchange. The importance of these observations is that they provide data in support... You do not currently have access to this content.