Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese

单核苷酸多态性 医学 强直性脊柱炎 SNP公司 逻辑回归 遗传关联 人口 遗传学 内科学 基因 基因型 生物 环境卫生
作者
Sean Davidson,Y. Liu,Patrick Danoy,Xin Wu,Gethin Thomas,Lei Jiang,Lingyun Sun,N. Wang,Junyong Han,Hedong Han,Peter M. Visscher,Matthew A. Brown,Huji Xu
出处
期刊:Annals of the Rheumatic Diseases [BMJ]
卷期号:70 (2): 289-292 被引量:101
标识
DOI:10.1136/ard.2010.133322
摘要

Objectives

Recent association studies by the Australo-Anglo-American Spondyloarthritis Consortium (TASC) in Caucasian European populations from Australia, North America and the UK have identified a number of genes as being associated with ankylosing spondylitis (AS). A candidate gene study in a Han Chinese population was performed based on these findings to identify associated genes in this population.

Methods

A case-control study was performed in a Han Chinese population of patients with AS (n=775) and controls (n=1587) from Shanghai and Nanjing. All patients met the modified New York criteria for AS. The cases and controls were genotyped for 115 single nucleotide polymorphisms (SNPs) tagging IL23R, ERAP1, STAT3, JAK2, TNFRSF1A and TRADD, as well as other confirmation SNPs from the TASC study, using the Sequenom iPlex and the ABI OpenArray platforms. Statistical analysis of genotyped SNPs was performed using the Cochran–Armitage test for trend and meta-analysis was performed using METAL. SNPs in AS-associated genes in this study were then imputed using MaCH, and association with AS tested by logistic regression.

Results

SNPs in TNFRSF1A (rs4149577, p=8.2×10−4), STAT3 (rs2293152, p=0.0015; rs1053005, p=0.017) and ERAP1 (rs27038, p=0.0091; rs27037, p=0.0092) were significantly associated with AS in Han Chinese. Association was also observed between AS and the intergenic region 2p15 (rs10865331, p=0.023). The lack of association between AS and IL23R in Han Chinese was confirmed (all SNPs p>0.1).

Conclusions

The study results demonstrate for the first time that genetic polymorphisms in STAT3, TNFRSF1A and 2p15 are associated with AS in Han Chinese, suggesting common pathogenic mechanisms for the disease in Chinese and Caucasian European populations. Furthermore, previous findings demonstrating that ERAP1, but not IL23R, is associated with AS in Chinese patients were confirmed.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
1秒前
2秒前
zhan20200503完成签到,获得积分10
3秒前
这个文献你有么完成签到,获得积分10
4秒前
小二郎应助lan采纳,获得10
4秒前
李颜龙完成签到,获得积分10
6秒前
liangye2222发布了新的文献求助10
6秒前
与山发布了新的文献求助10
7秒前
7秒前
高手如林完成签到,获得积分10
8秒前
高铭泽完成签到,获得积分20
8秒前
Hengjian_Pu完成签到,获得积分10
8秒前
友好胜完成签到 ,获得积分10
8秒前
坦率白萱发布了新的文献求助10
9秒前
方翔应助林白采纳,获得100
9秒前
量子星尘发布了新的文献求助10
9秒前
Vresty完成签到,获得积分10
11秒前
糯米团的完成签到 ,获得积分10
13秒前
13秒前
Yunsong发布了新的文献求助10
13秒前
黑猫完成签到,获得积分20
14秒前
热心市民小红花应助千余采纳,获得10
15秒前
15秒前
16秒前
lan完成签到,获得积分10
16秒前
火星上念梦发布了新的文献求助150
16秒前
Enckson完成签到,获得积分10
17秒前
火星上的羽毛完成签到,获得积分10
18秒前
留留完成签到,获得积分10
19秒前
lan发布了新的文献求助10
19秒前
我爱金哥发布了新的文献求助10
19秒前
20秒前
小叶曲完成签到,获得积分10
20秒前
23秒前
czl完成签到,获得积分10
26秒前
精明谷发布了新的文献求助10
27秒前
香查朵完成签到,获得积分10
27秒前
lu应助wf采纳,获得10
27秒前
28秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988868
求助须知:如何正确求助?哪些是违规求助? 3531255
关于积分的说明 11253071
捐赠科研通 3269858
什么是DOI,文献DOI怎么找? 1804822
邀请新用户注册赠送积分活动 881994
科研通“疑难数据库(出版商)”最低求助积分说明 809035