Direct Functionalization of Tetrahydrofuran and 1,4‐Dioxane: Nickel‐Catalyzed Oxidative C(sp3)H Arylation

Angewandte Chemie International EditionVolume 52, Issue 16 p. 4453-4456 Communication Direct Functionalization of Tetrahydrofuran and 1,4-Dioxane: Nickel-Catalyzed Oxidative C(sp3)H Arylation† Dong Liu, Dong Liu College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/ These authors contributed equally to this work.Search for more papers by this authorDr. Chao Liu, Dr. Chao Liu College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/ These authors contributed equally to this work.Search for more papers by this authorHeng Li, Heng Li College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/Search for more papers by this authorProf. Aiwen Lei, Corresponding Author Prof. Aiwen Lei [email protected] College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/ State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 (P. R. China)College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/===Search for more papers by this author Dong Liu, Dong Liu College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/ These authors contributed equally to this work.Search for more papers by this authorDr. Chao Liu, Dr. Chao Liu College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/ These authors contributed equally to this work.Search for more papers by this authorHeng Li, Heng Li College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/Search for more papers by this authorProf. Aiwen Lei, Corresponding Author Prof. Aiwen Lei [email protected] College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/ State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 (P. R. China)College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072 (P. R. China) http://www.chem.whu.edu.cn/GCI_WebSite/===Search for more papers by this author First published: 19 March 2013 https://doi.org/10.1002/anie.201300459Citations: 259 † This work was supported by the 973 Program (2012CB725302), the National Natural Science Foundation of China (21025206 and 21272180) and the China Postdoctoral Science Foundation funded project (2012M521458). We are also grateful for support from the Program for Changjiang Scholars and Innovative Research Team in University (IRT1030). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract CHoose nickel: The nickel-catalyzed oxidative arylation of C(sp3)H bonds has been achieved. Several substituted arylboronic acids and various C(sp3)H bonds were found to be suitable substrates for this novel transformation, which is likely to proceed through a radical pathway. This method allows the introduction of simple ether derivatives to construct α-arylated ethers. FG=functional group. Citing Literature Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description anie_201300459_sm_miscellaneous_information.pdf829.9 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume52, Issue16April 15, 2013Pages 4453-4456 RelatedInformation