Microneedle-Based Intradermal Versus Subcutaneous Administration of Regular Human Insulin or Insulin Lispro: Pharmacokinetics and Postprandial Glycemic Excursions in Patients with Type 1 Diabetes

医学 餐后 药代动力学 lispro胰岛素 血糖性 交叉研究 胰岛素 1型糖尿病 曲线下面积 加药 糖尿病 药效学 麻醉 普通胰岛素 内科学 内分泌学 胃肠病学 低血糖 安慰剂 病理 替代医学
作者
Ronald J. Pettis,Laurence Hirsch,Christoph Kapitza,Leszek Nosek,Ulrike Hövelmann,Heinz-Joerg Kurth,Diane Sutter,Noel G. Harvey,Lutz Heinemann
出处
期刊:Diabetes Technology & Therapeutics [Mary Ann Liebert]
卷期号:13 (4): 443-450 被引量:66
标识
DOI:10.1089/dia.2010.0183
摘要

Background: This study assessed pharmacokinetics (PK) and pharmacodynamic postprandial glycemia (PPG) in patients with type 1 diabetes mellitus (T1DM) after a standardized liquid meal following insulin lispro (IL) or regular human insulin (RHI) given by microneedle-based intradermal (ID) versus subcutaneous (SC) delivery. Research Design and Methods: In this randomized, open-label, five-way crossover study, 29 T1DM patients received IL and RHI (0.125 U/kg) at 2 min and 17 min premeal, respectively, by both the SC and ID routes and also received RHI by the ID route at 2 min premeal. Blood glucose was stabilized at 120 mg/dL prior to a standardized 82-g carbohydrate liquid meal. ID delivery used a 34-gauge 1.5-mm steel microneedle, and SC delivery used a 31-gauge 8-mm syringe needle. Results: The 90-min PPG (blood glucose area under the curve for 0–1.5 h) for ID RHI was 14% lower than SC RHI at −17 min (P < 0.0001) and 11% lower than ID RHI at −2 min (P = 0.0006). PPG did not differ between ID RHI and SC IL, both at −2 min (P = 0.8345). ID IL PPG was lower than SC, both at −2 min, but not significantly (P = 0.10). Both ID IL and ID RHI PK data showed significantly faster uptake and time to maximum concentration, higher maximum concentration, and shorter systemic circulating duration versus SC dosing. ID IL and RHI delivery was generally well tolerated. Conclusions: PPG with RHI administered ID via microneedle was improved versus SC delivery when dosed 17 min premeal. ID RHI provided similar control of PPG as SC IL immediately premeal. Further studies of ID insulin delivery via steel microneedles are warranted.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1565532470完成签到,获得积分10
刚刚
健壮不斜完成签到 ,获得积分10
1秒前
坦率绮山完成签到 ,获得积分10
1秒前
兰格格完成签到,获得积分10
1秒前
任我行完成签到,获得积分10
1秒前
小蘑菇应助如果我沉默采纳,获得10
1秒前
Gao_Z_X完成签到 ,获得积分10
1秒前
想个名字发布了新的文献求助30
1秒前
柴胡完成签到,获得积分10
1秒前
强强强强完成签到,获得积分10
1秒前
1秒前
Zo发布了新的文献求助10
2秒前
卡里的乏味完成签到,获得积分10
3秒前
小陈完成签到,获得积分10
4秒前
星辰大海应助南风喜欢采纳,获得10
5秒前
科研通AI2S应助bing采纳,获得10
6秒前
科研通AI2S应助bing采纳,获得10
6秒前
6秒前
new_vision完成签到,获得积分10
6秒前
园艺小学生完成签到,获得积分10
6秒前
李爱国应助forg采纳,获得10
7秒前
Sissi完成签到,获得积分10
8秒前
aibiotech完成签到,获得积分10
8秒前
8秒前
xng完成签到,获得积分10
9秒前
9秒前
Seven完成签到,获得积分10
10秒前
邵初蓝完成签到,获得积分10
10秒前
10秒前
淡然寒蕾完成签到,获得积分10
10秒前
迷路凌柏完成签到 ,获得积分10
10秒前
yydsyk完成签到,获得积分10
11秒前
科研通AI5应助如果我沉默采纳,获得10
11秒前
樊孟完成签到,获得积分10
11秒前
11秒前
11秒前
12秒前
难过的小甜瓜完成签到,获得积分10
12秒前
将就小白完成签到,获得积分10
12秒前
12秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Structural Load Modelling and Combination for Performance and Safety Evaluation 800
Conference Record, IAS Annual Meeting 1977 610
Virulence Mechanisms of Plant-Pathogenic Bacteria 500
白土三平研究 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3556082
求助须知:如何正确求助?哪些是违规求助? 3131635
关于积分的说明 9392313
捐赠科研通 2831483
什么是DOI,文献DOI怎么找? 1556442
邀请新用户注册赠送积分活动 726605
科研通“疑难数据库(出版商)”最低求助积分说明 715912