柯萨奇病毒
生物
细胞凋亡
心肌炎
受体
心肌细胞
细胞生物学
跨膜蛋白
胚胎干细胞
程序性细胞死亡
免疫组织化学
病理
癌症研究
免疫学
内科学
医学
病毒
遗传学
肠道病毒
基因
作者
Damon R. Asher,Anna M. Cerny,Sarah R. Weiler,James W. Horner,Marilyn L. Keeler,Mychell A. Neptune,Stephen N. Jones,Roderick T. Bronson,Ronald A. DePinho,Robert W. Finberg
出处
期刊:Genesis
[Wiley]
日期:2005-05-12
卷期号:42 (2): 77-85
被引量:88
摘要
The coxsackievirus and adenovirus receptor (CAR) is a transmembrane protein that is known to be a site of viral attachment and entry, but its physiologic functions are undefined. CAR expression is maximal in neonates and wanes rapidly after birth in organs such as heart, muscle, and brain, suggesting that CAR plays a role in the development of these tissues. Here, we show that CAR deficiency resulted in an embryonic lethal condition associated with cardiac defects. Specifically, commencing approximately 10.5 days postconception (dpc), CAR-/- cardiomyocytes exhibited regional apoptosis evidenced by both histopathologic features of cell death and positive staining for the apoptotic marker cleaved caspase 3. CAR-/- fetuses invariably suffered from degeneration of the myocardial wall and thoracic hemorrhaging, leading to death by 11.5 dpc. These findings are consistent with the view that CAR provides positive survival signals to cardiomyocytes that are essential for normal heart development.
科研通智能强力驱动
Strongly Powered by AbleSci AI