磁刺激
神经康复
神经科学
神经学
促进
刺激
皮质神经元
医学
神经影像学
心理学
脑刺激
康复
作者
Álvaro Pascual‐Leone,Josep M. Tormos,Julian Paul Keenan,Francisco Tarazona,Carlos Cañete,Maria Dolores Catalá
出处
期刊:Journal of Clinical Neurophysiology
[Ovid Technologies (Wolters Kluwer)]
日期:1998-07-01
卷期号:15 (4): 333-343
被引量:747
标识
DOI:10.1097/00004691-199807000-00005
摘要
Transcranial magnetic stimulation (TMS) can be applied in different paradigms to obtain a measure of various aspects of cortical excitability. These different TMS paradigms provide information about different neurotransmitter systems, enhance our understanding about the pathophysiology of neuropsychiatric conditions, and in the future may be helpful as a guide for pharmacological interventions. In addition, repetitive TMS (rTMS) modulates cortical excitability beyond the duration of the rTMS trains themselves. Depending on rTMS parameters, a lasting inhibition or facilitation of cortical excitability can be induced. These effects can be demonstrated neurophysiologically or by combining rTMS with neuroimaging techniques. The effects do not remain limited to the cortical area directly targeted by rTMS, but affect a wider neural network transynaptically. Modulation of cortical excitability by rTMS may in the future be useful not only as a research tool but also as a therapeutic intervention in neurology, psychiatry, and neurorehabilitation.
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