Identifying Specific Conformations by Using a Carbohydrate Scaffold: Discovery of Subtype‐Selective LPA‐Receptor Agonists and an Antagonist

Stable and potent subtype-selective lysophosphatidic acid (LPA) analogues (agonists and an antagonist) were developed by using carbohydrates as a core structure (see scheme). An array of molecules with the recognition motifs of LPA (a phosphate anion, an oleoyl group, and a hydrogen-bond acceptor) attached to carbohydrate isomers in different three-dimensional arrangements were tested for LPA-receptor activation or inhibition. R=alkyl. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z54065_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.