溶血磷脂酸
敌手
化学
碳水化合物
接受者
受体
氢键
立体化学
小分子
分子
生物化学
有机化学
物理
凝聚态物理
作者
Yoko Tamaruya,Masato Suzuki,Goshu Kamura,Motomu Kanai,Kotaro Hama,Kumiko Shimizu,Junken Aoki,Hiroyuki Arai,Masakatsu Shibasaki
标识
DOI:10.1002/anie.200454065
摘要
Stable and potent subtype-selective lysophosphatidic acid (LPA) analogues (agonists and an antagonist) were developed by using carbohydrates as a core structure (see scheme). An array of molecules with the recognition motifs of LPA (a phosphate anion, an oleoyl group, and a hydrogen-bond acceptor) attached to carbohydrate isomers in different three-dimensional arrangements were tested for LPA-receptor activation or inhibition. R=alkyl. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z54065_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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