口语流利性测试
脱氧血红蛋白
前额叶皮质
痴呆
心理学
大脑活动与冥想
阿尔茨海默病
听力学
背外侧前额叶皮质
神经科学
内科学
疾病
医学
认知
脑电图
血红蛋白
神经心理学
作者
Martin J. Herrmann,J. Langer,Christian Jacob,Ann‐Christine Ehlis,Andreas J. Fallgatter
标识
DOI:10.1097/jgp.0b013e3180cc1fbc
摘要
Objective Near-infrared spectroscopy (NIRS) is an optical method to measure changes in the concentration of oxygenated hemoglobin (O2Hb) and deoxygenated hemoglobin (HHb) in the vascular system of the brain tissue. Because NIRS is easy to assess and does not have any side effects, it seems perfectly suitable for functional measurements in psychiatric patients or fragile subjects. As previous research suggested changes in functional brain activation in prefrontal brain areas of patients with dementia, the aim of this study was to replicate these findings by means of multichannel NIRS. Methods In the present study, the authors investigated 16 patients with Alzheimer disease and 16 healthy subjects (similar in age and sex) during performance of a verbal fluency task. Results The results clearly showed an activation pattern during active phase as compared to baseline phase in the form of decreases in HHb and increases in O2Hb, with a reduced increase of O2Hb for patients. Conclusion These results indicate a diminished activation of the dorsolateral prefrontal cortex in patients with Alzheimer disease. Future research has to show whether this decreased activation pattern might be a suitable predictor for the effectiveness of treatment in dementias. Near-infrared spectroscopy (NIRS) is an optical method to measure changes in the concentration of oxygenated hemoglobin (O2Hb) and deoxygenated hemoglobin (HHb) in the vascular system of the brain tissue. Because NIRS is easy to assess and does not have any side effects, it seems perfectly suitable for functional measurements in psychiatric patients or fragile subjects. As previous research suggested changes in functional brain activation in prefrontal brain areas of patients with dementia, the aim of this study was to replicate these findings by means of multichannel NIRS. In the present study, the authors investigated 16 patients with Alzheimer disease and 16 healthy subjects (similar in age and sex) during performance of a verbal fluency task. The results clearly showed an activation pattern during active phase as compared to baseline phase in the form of decreases in HHb and increases in O2Hb, with a reduced increase of O2Hb for patients. These results indicate a diminished activation of the dorsolateral prefrontal cortex in patients with Alzheimer disease. Future research has to show whether this decreased activation pattern might be a suitable predictor for the effectiveness of treatment in dementias.
科研通智能强力驱动
Strongly Powered by AbleSci AI