体内
生物
免疫学
树突状细胞
细胞分化
髓样
免疫疗法
免疫系统
基因
遗传学
作者
Carlos Ardavı́n,Gloria Martı́nez del Hoyo,Pilar Martı́n,Fabienne Anjuère,Cristina Fernández-Arias,Alvaro Rodrı́guez Marı́n,Sara Ruiz,Verónica Parrillas,Héctor Hernández‐Vargas
标识
DOI:10.1016/s1471-4906(01)02059-2
摘要
Despite extensive, recent research on the development of dendritic cells (DCs), their origin is a controversial issue in immunology, with important implications regarding their use in cancer immunotherapy. Although, under defined experimental conditions, DCs can be generated from myeloid or lymphoid precursors, the differentiation pathways that generate DCs in vivo remain unknown largely. Indeed, experimental results suggest that the in vivo differentiation of a particular DC subpopulation could be unrelated to its possible experimental generation. Nevertheless, the analysis of DC differentiation by in vivo and in vitro experimental systems could provide important insights into the control of the physiological development of DCs and constitutes the basis of a model of common DC differentiation that we propose.
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