A TOTAL SYNTHESIS OF COENZYME A BY OXIDATION-REDUCTION CONDENSATION

Abstract A total synthesis of coenzyme A by utilization of the oxidation-reduction condensation in each important steps is described. Adenosine 2′ ,3′ -cyclic phosphate 5′ -phosphoromorpholidate and pantethine, important intermediates of coenzyme A, were prepared starting from adenosine 2′ (3′-) phosphate and pantothenoic acid in 60% and 80% yields, respectively, mainly by the use of triphenylphosphine and 2,2′ -dipyridyl disulfide as coupling reagents.