医学
黄嘌呤氧化酶
尿酸
嘌呤
慢性伤口
伤口愈合
黄嘌呤
酶
生物化学
内科学
外科
化学
作者
Melissa L. Fernandez,Zee Upton,Helen Edwards,Kathleen Finlayson,Gary K. Shooter
标识
DOI:10.1111/j.1742-481x.2011.00870.x
摘要
Chronic venous leg ulcers are a major health issue and represent an often overlooked area of biomedical research. Nevertheless, it is becoming increasingly evident that new approaches to enhance healing outcomes may arise through better understanding the processes involved in the formation of chronic wounds. We have for the first time shown that the terminal purine catabolite uric acid (UA) is elevated in wound fluid (WF) from chronic venous leg ulcers with relative concentrations correlating with wound chronicity. We have also shown a corresponding depletion in UA precursors, including adenosine, with increased wound severity. Further, we have shown that xanthine oxidase, the only enzyme in humans that catalyses the production of UA in conjunction with a burst of free radicals, is active in chronic WF. Taken together, this provides compelling evidence that xanthine oxidase may play a critical role in the formation of chronic wounds by prolonging the inflammatory process.
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