Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and ‘self-microemulsifying’ drug delivery systems

生物利用度 化学 药品 剂型 药物输送 色谱法 脂类消化 溶解度 药理学 有机化学 医学 脂肪酶
作者
Colin W. Pouton
出处
期刊:European Journal of Pharmaceutical Sciences [Elsevier]
卷期号:11: S93-S98 被引量:1161
标识
DOI:10.1016/s0928-0987(00)00167-6
摘要

'Lipid' formulations for oral administration of drugs generally consist of a drug dissolved in a blend of two or more excipients, which may be triglyceride oils, partial glycerides, surfactants or co-surfactants. The primary mechanism of action which leads to improved bioavailability is usually avoidance, or partial avoidance, of the slow dissolution process which limits the bioavailability of hydrophobic drugs from solid dosage forms. Ideally the formulation allows the drug to remain in a dissolved state throughout its transit through the gastrointestinal tract. The availability of the drug for absorption can be enhanced by presentation of the drug as a solubilizate within a colloidal dispersion. This objective can be achieved by formulation of the drug in a self-emulsifying system or alternatively by taking advantage of the natural process of triglyceride digestion. In practice 'lipid' formulations range from pure oils, at one extreme, to blends which contain a substantial proportion of hydrophilic surfactants or cosolvents. Knowledge of the efficiency of emulsification of these formulations, the nature of the colloidal system formed by dispersion, their susceptibility to digestion, and the subsequent fate of the drug is desirable for formulation. Yet the literature on this subject is limited, so this article represents part review and part commentary on current status of lipid formulations. A simple classification system for lipid formulations, based on the polarity of the blend and reviewed here, will help comparison of data between laboratories. Priorities for future work are discussed. More data is needed on the solubility of drugs in various types of formulations, and in particular, on the relationship between the physical chemistry of the drug and its fate, subsequent to dilution and digestion of the formulation in the lumen of the gastrointestinal tract. The mechanisms of action and practical uses of each type of lipid formulation are discussed.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
dms完成签到,获得积分10
1秒前
萱1988完成签到,获得积分10
1秒前
桐桐应助迷人的沛山采纳,获得10
1秒前
倚门回首完成签到,获得积分10
1秒前
崔崔完成签到,获得积分10
2秒前
梦在彼岸完成签到,获得积分10
2秒前
柔弱的兔子完成签到,获得积分10
3秒前
苏邑发布了新的文献求助10
3秒前
3秒前
学术混子完成签到,获得积分10
3秒前
4秒前
haimianxi完成签到,获得积分10
4秒前
zy发布了新的文献求助10
5秒前
personking完成签到,获得积分10
5秒前
Sml发布了新的文献求助10
5秒前
5秒前
迪琛发布了新的文献求助10
6秒前
坦率的松发布了新的文献求助10
6秒前
6秒前
6秒前
月亮发布了新的文献求助10
6秒前
7秒前
自信夜春完成签到,获得积分10
7秒前
领导范儿应助青灿笑采纳,获得10
8秒前
MYYY完成签到,获得积分10
8秒前
年轻契发布了新的文献求助10
8秒前
11发布了新的文献求助10
9秒前
嘻嘻嘻发布了新的文献求助10
9秒前
我要啃木头完成签到 ,获得积分10
9秒前
9秒前
苏邑完成签到,获得积分10
10秒前
年轻上线完成签到,获得积分10
10秒前
zgy1106完成签到,获得积分10
11秒前
爱科研完成签到,获得积分20
11秒前
麻师长发布了新的文献求助10
11秒前
12秒前
12秒前
小艾艾麦仑完成签到,获得积分10
13秒前
谨慎傲旋完成签到 ,获得积分10
13秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Very-high-order BVD Schemes Using β-variable THINC Method 870
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
Fundamentals of Dispersed Multiphase Flows 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3253360
求助须知:如何正确求助?哪些是违规求助? 2895934
关于积分的说明 8289128
捐赠科研通 2564780
什么是DOI,文献DOI怎么找? 1392497
科研通“疑难数据库(出版商)”最低求助积分说明 652223
邀请新用户注册赠送积分活动 629528