Association Between the Various Mutations in Viral Core Promoter Region to Different Stages of Hepatitis B, Ranging of Asymptomatic Carrier State to Hepatocellular Carcinoma

肝细胞癌 肝硬化 医学 乙型肝炎病毒 基因型 无症状携带者 胃肠病学 内科学 乙型肝炎 无症状的 病毒学 病毒 基因 生物 遗传学
作者
Jianhua Yin,Jiaxin Xie,Shijian Liu,Hongwei Zhang,Lei Han,Wenying Lu,Qiuxia Shen,Guozhang Xu,Hongjun Dong,Jie Shen,Jun Zhang,Jiankang Han,Lin Wang,Yan Liu,Fan Wang,Jun Zhao,Qian Zhang,Wu Ni,Hongyang Wang,Guangwen Cao
出处
期刊:The American Journal of Gastroenterology [American College of Gastroenterology]
卷期号:106 (1): 81-92 被引量:132
标识
DOI:10.1038/ajg.2010.399
摘要

The objective of this study was to determine the association of 19 mutations with frequencies ≥ 10% in the core promoter region of hepatitis B virus (HBV) with chronic hepatitis B (CHB), liver cirrhosis, and hepatocellular carcinoma (HCC).Eight hundred forty-six asymptomatic hepatitis B surface antigen carriers (ASCs), 235 CHB patients, 188 cirrhosis patients, and 190 HCC patients with intact data of HBV genotyping, DNA sequencing, and serological parameters were studied. Nucleotides with the highest frequencies in HBV genotypes B and C from all ASCs were treated as wild-type nucleotides.Mutations at nt.1674, nt.1719, nt.1762, nt.1764, nt.1846, nt.1896, and nt.1913 in genotype C were significantly associated with CHB, cirrhosis, and HCC, as compared with ASCs. C1673T, A1726C, A1727T, C1730G, C1766T, T1768A, C1773T, and C1799G in genotype C were significantly associated with cirrhosis compared with the CHB patients, whereas these mutations were inversely associated with HCC compared with the cirrhosis patients. Multivariate regression analyses showed that age, male, abnormal alanine aminotransferase (ALT), T1768A, A1762T/G1764A, and A1846T were independently associated with cirrhosis compared with ASCs and the patients with CHB. Age, abnormal ALT, HBV DNA (≥10(4) copies/ml), genotype C, C1653T, T1674C/G, T1753V, and A1762T/G1764A were independently associated with HCC compared with those without HCC. Haplotypic carriages with two or more HBV mutations were significantly associated with HCC. T1674C/G, C1653T, and T1753V were specific for HCC. A1762T/G1764A had a moderate sensitivity and specificity for HCC.C1673T, A1726C, A1727T, C1730G, C1766T, T1768A, C1773T, and C1799G in genotype C are specific for cirrhosis. A1846T and T1674C/G are novel factors independently associated with cirrhosis and HCC, respectively.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
DrKe完成签到,获得积分10
刚刚
情怀应助科研通管家采纳,获得10
1秒前
天天快乐应助科研通管家采纳,获得10
1秒前
科研通AI2S应助科研通管家采纳,获得10
1秒前
跨进行完成签到,获得积分10
1秒前
orixero应助科研通管家采纳,获得20
1秒前
天天快乐应助科研通管家采纳,获得10
2秒前
科研通AI2S应助科研通管家采纳,获得10
2秒前
华仔应助科研通管家采纳,获得10
2秒前
Jessica应助科研通管家采纳,获得30
2秒前
科研通AI2S应助科研通管家采纳,获得10
2秒前
英俊的铭应助科研通管家采纳,获得10
2秒前
汉堡包应助科研通管家采纳,获得10
2秒前
orixero应助科研通管家采纳,获得10
2秒前
2秒前
zhang@完成签到,获得积分10
2秒前
2秒前
3秒前
enen发布了新的文献求助10
3秒前
qhy完成签到,获得积分10
3秒前
HCLonely应助siccy采纳,获得10
3秒前
小马甲应助reup采纳,获得10
3秒前
韦老虎发布了新的文献求助10
3秒前
诺诺诺诺呀完成签到,获得积分10
3秒前
传奇3应助hh0采纳,获得10
4秒前
动听的囧完成签到 ,获得积分10
4秒前
爆米花应助xytyyy采纳,获得10
4秒前
QC发布了新的文献求助30
4秒前
yuandfish完成签到,获得积分20
5秒前
Redamancy完成签到 ,获得积分10
5秒前
JiangXueBa发布了新的文献求助10
6秒前
biancaliu发布了新的文献求助10
7秒前
Zoey应助JxJ采纳,获得10
7秒前
跨进行发布了新的文献求助10
7秒前
7秒前
7秒前
8秒前
8秒前
8秒前
Sean发布了新的文献求助10
8秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Very-high-order BVD Schemes Using β-variable THINC Method 870
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
Fundamentals of Dispersed Multiphase Flows 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3254828
求助须知:如何正确求助?哪些是违规求助? 2897067
关于积分的说明 8295479
捐赠科研通 2566125
什么是DOI,文献DOI怎么找? 1393555
科研通“疑难数据库(出版商)”最低求助积分说明 652539
邀请新用户注册赠送积分活动 630155