Recent pharmaceutical engineered approaches as prophylaxis and management of frostbite

Frostbite injury is caused to tissue or organ on exposure of cold or frozen conditions. Previously this problem is associated with military personnel deployed at high altitudes. But nowadays frostbite falls within the scope of civilians also due to modernization and mobilization. Deep frostbite results in necrosis and might causes amputation when the situation exaggerates. The underlying mechanism of pathophysiology pertaining to frostbite and therapy for it is not explored so far. There are not many research findings that pertain to pathophysiology and treatment advancements in this area. The current review highlights the current advancements in terms of drug delivery especially covering the area of nanoplatforms. This review will pave the way for the scientific world to explore the hidden truth of frostbite about pathophysiology and open the new doors for better therapeutic options.