先天免疫系统
炎症体
免疫学
免疫
疾病
炎症
程序性细胞死亡
获得性免疫系统
核酸
生物
医学
免疫系统
遗传学
细胞凋亡
病理
作者
Rajendra Karki,Thirumala‐Devi Kanneganti
标识
DOI:10.1016/j.it.2023.01.001
摘要
ADAR1 and ZBP1 are the only two mammalian proteins that contain Zα domains, which are thought to bind to nucleic acids in the Z-conformation. These two molecules are crucial in regulating diverse biological processes. While ADAR1-mediated RNA editing supports host survival and development, ZBP1-mediated immune responses provide host defense against infection and disease. Recent studies have expanded our understanding of the functions of ADAR1 and ZBP1 beyond their classical roles and established their fundamental regulation of innate immune responses, including NLRP3 inflammasome activation, inflammation, and cell death. Their roles in these processes have physiological impacts across development, infectious and inflammatory diseases, and cancer. In this review, we discuss the functions of ADAR1 and ZBP1 in regulating innate immune responses in development and disease.
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