核糖核酸
表观遗传学
生物
小RNA
翻译(生物学)
RNA编辑
信使核糖核酸
癌症
非编码RNA
计算生物学
卵巢癌
遗传学
基因
癌症研究
生物信息学
作者
Lele Ye,Xin Yao,Bin Xu,Wenwen Chen,Han Liang,Xinya Tong,Fang Su,Ruanmin Zou,Yingying Hu,Zhibin Wang,Dan Xiang,Qiaoai Lin,Shiyu Feng,Xiangyang Xue,Gangqiang Guo
摘要
Ovarian cancer (OC) is the most common female cancer worldwide. Patients with OC have high mortality because of its complex and poorly understood pathogenesis. RNA epigenetic modifications, such as m6 A, m1 A, and m5 C, are closely associated with the occurrence and development of OC. RNA modifications can affect the stability of mRNA transcripts, nuclear export of RNAs, translation efficiency, and decoding accuracy. However, there are few overviews that summarize the link between m6 A RNA modification and OC. Here, we discuss the molecular and cellular functions of different RNA modifications and how their regulation contributes to the pathogenesis of OC. By improving our understanding of the role of RNA modifications in the etiology of OC, we provide new perspectives for their use in OC diagnosis and treatment. This article is categorized under: RNA Processing > RNA Editing and Modification RNA in Disease and Development > RNA in Disease.
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