病理
间变性淋巴瘤激酶
组织细胞增多症
肺
医学
异型性
基因重排
生物
肺癌
内科学
疾病
恶性胸腔积液
生物化学
基因
作者
Ali Kubilay Kolik,Doğu Vurallı Bakkaloğlu,İsmail Yılmaz,Mehmet Semih Çakır,Gülçin Yeğen,Murat Kara,Yasemin Özlük
标识
DOI:10.1177/10668969241271372
摘要
We hereby report a patient with ALK-positive histiocytosis with localized lung involvement. A 47-year-old woman presented with a solitary pulmonary nodule in the left upper lobe, 7 months after COVID infection. A well-defined 15 mm yellow mass was found in trisegmentectomy specimen. Histopathological examination revealed that the mass was composed of epithelioid and spindle cells with foamy cytoplasms. No necrosis, pleomorphism, or nuclear atypia was detected. The cells were positive for CD68, CD163, PU.1, ALK and negative for KRT, smooth muscle actin (SMA), S100, Melan-A, CD34, STAT6, and BRAF VE1. Flourescence in situ hybridization demonstrated ALK gene rearrangement, and next generation sequencing confirmed EML4::ALK fusion. Lung involvement in ALK-positive histiocytosis is characterized by the presence of pulmonary nodules, which can be seen in all forms of the disease. However, lung involvement is rarely seen in single-system ALK-positive histiocytosis. Our report represents the fourth documented instance of localized lung involvement in ALK-positive histiocytosis, an exceedingly rare occurrence, and it is the third instance with available molecular data.
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