着丝粒
PLK1
细胞生物学
Polo样激酶
动细胞
生物
细胞周期蛋白依赖激酶
细胞周期
遗传学
染色体
细胞
基因
作者
Duccio Conti,Arianna Esposito Verza,Marion E. Pesenti,Verena Cmentowski,Ingrid R. Vetter,Dongqing Pan,Andrea Musacchio
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2024-09-05
卷期号:385 (6713): 1091-1097
被引量:1
标识
DOI:10.1126/science.ado5178
摘要
The centromere, a chromosome locus defined by the histone H3–like protein centromeric protein A (CENP-A), promotes assembly of the kinetochore to bind microtubules during cell division. Centromere maintenance requires CENP-A to be actively replenished by dedicated protein machinery in the early G 1 phase of the cell cycle to compensate for its dilution after DNA replication. Cyclin-dependent kinases (CDKs) limit CENP-A deposition to once per cell cycle and function as negative regulators outside of early G 1 . Antithetically, Polo-like kinase 1 (PLK1) promotes CENP-A deposition in early G 1 , but the molecular details of this process are still unknown. We reveal here a phosphorylation network that recruits PLK1 to the deposition machinery to control a conformational switch required for licensing the CENP-A deposition reaction. Our findings clarify how PLK1 contributes to the epigenetic maintenance of centromeres.
科研通智能强力驱动
Strongly Powered by AbleSci AI