材料科学
肽
纳米颗粒
信号(编程语言)
细胞穿透肽
纳米技术
细胞
生物物理学
生物化学
生物
计算机科学
程序设计语言
作者
Melanie Walter,Merlin Bresinsky,Oliver Zimmer,Steffen Pockes,Achim Goepferich
标识
DOI:10.1021/acsami.4c07821
摘要
A major bottleneck diminishing the therapeutic efficacy of various drugs is that only small proportions of the administered dose reach the site of action. One promising approach to increase the drug amount in the target tissue is the delivery via nanoparticles (NPs) modified with ligands of cell surface receptors for the selective identification of target cells. However, since receptor binding can unintentionally trigger intracellular signaling cascades, our objective was to develop a receptor-independent way of NP uptake. Cell-penetrating peptides (CPPs) are an attractive tool since they allow efficient cell membrane crossing. So far, their applicability is severely limited as their uptake-promoting ability is nonspecific. Therefore, we aimed to achieve a conditional CPP-mediated NP internalization exclusively into target cells. We synthesized different CPP candidates and investigated their influence on nanoparticle stability, ζ-potential, and uptake characteristics in a core-shell nanoparticle system consisting of poly(lactid-
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