Apelin - A New Kid on the Block in Periodontology.

医学 牙周病学 阿佩林 牙科 内科学 受体
作者
Pablo Cores Ziskoven,Andressa Vilas Boas Nogueira,Onur Yoldaş,Nurcan Buduneli,Philipp S. Wild,Thomas Koeck,James Deschner
出处
期刊:PubMed 卷期号:22: 417-424 被引量:1
标识
DOI:10.3290/j.ohpd.b5695264
摘要

Periodontitis is associated with numerous systemic diseases, and it has been shown that these associations are partly causal in nature. It is assumed that such interactions between periodontal and systemic diseases are also medi- ated via adipokines. Apelin, an adipokine about which there is little research in the dental field, is also produced together with its receptor in periodontal cells. The aim of this review was to summarize the currently available literature on the apelin-APJ system to better understand the pathomechanistic relationship between periodontitis and obesity and to de- termine the potential clinical relevance of apelin for diagnostics and therapy. In vitro studies suggest that apelin can en- hance bacterial-induced synthesis of proinflammatory and proteolytic molecules, indicating a significant etiopathogenic role of this adipokine. Since serum levels of apelin are elevated in diabetes and/or obesity, it is possible that such sys- temic diseases promote the development and progression of periodontitis via apelin. On the other hand, it is also conceivable that apelin from the periodontium influences such systemic diseases. Further research is needed to better understand the role of apelin in the periodontium and the entire oral cavity, but also in the interactions between periodontal and sys- temic diseases. In particular, clinical intervention studies are needed to further decipher the etiopathogenic role of apelin in periodontitis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
歇洛克完成签到,获得积分10
1秒前
cao完成签到,获得积分20
1秒前
为你博弈完成签到,获得积分10
2秒前
2秒前
于情信芳完成签到,获得积分10
2秒前
庚小马发布了新的文献求助10
2秒前
淡然妙竹发布了新的文献求助10
3秒前
炒栗子发布了新的文献求助10
3秒前
晴云发布了新的文献求助10
3秒前
4秒前
PHW完成签到,获得积分10
4秒前
monly应助Fin2046采纳,获得30
5秒前
Hello应助JJG采纳,获得10
5秒前
李健的小迷弟应助WJH采纳,获得10
5秒前
7秒前
ty发布了新的文献求助10
7秒前
刘逸藩完成签到,获得积分10
7秒前
yulian完成签到,获得积分10
8秒前
chemhub完成签到,获得积分10
8秒前
歇洛克发布了新的文献求助10
8秒前
Lee发布了新的文献求助10
8秒前
8秒前
慢慢发布了新的文献求助10
9秒前
香蕉觅云应助科多兽骑士采纳,获得10
10秒前
hao发布了新的文献求助10
10秒前
天真依玉完成签到,获得积分10
10秒前
鳗鱼鸽子完成签到,获得积分10
10秒前
炒栗子完成签到,获得积分10
10秒前
和平港湾完成签到,获得积分10
11秒前
11秒前
淡然妙竹完成签到,获得积分20
11秒前
量子星尘发布了新的文献求助10
12秒前
13秒前
复杂的海完成签到,获得积分10
13秒前
leo发布了新的文献求助10
14秒前
Lee完成签到,获得积分10
14秒前
surain完成签到,获得积分10
16秒前
贪玩的怜南完成签到,获得积分10
16秒前
16秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038569
求助须知:如何正确求助?哪些是违规求助? 3576279
关于积分的说明 11374944
捐赠科研通 3305979
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815048