医学
肾病
肾小球肾炎
肾病科
免疫学
肾活检
免疫球蛋白A
发病机制
活检
肾
肾脏疾病
病理
抗体
内科学
免疫球蛋白G
内分泌学
糖尿病
作者
Małgorzata Mizerska-Wasiak
出处
期刊:Pediatric Nephrology
[Springer Science+Business Media]
日期:2022-08-02
卷期号:38 (5): 1439-1448
被引量:4
标识
DOI:10.1007/s00467-022-05644-9
摘要
IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide. It is diagnosed based on clinical and histological features including predominant IgA deposits in kidney biopsy. The multi-hit theory, based on the production of GDIgA1 and anti-GDIgA1 antibodies, and complement activation via alternative and lectin pathways and also a genetic tendency are crucial in the pathogenesis of IgAN. The aim of the present review is to summarize the utility of routine diagnostic tests in IgA nephropathy, such as IgA and C3 in serum and kidney biopsy specimens, for predicting the disease progression. The paper also contains data on new markers used in the diagnosis and prognosis of IgA nephropathy.
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