A CTL‐Inspired Killing System Using Ultralow‐Dose Chemical‐Drugs to Induce a Pyroptosis‐Mediated Antitumor Immune Function (Adv. Mater. 13/2024)

Advanced MaterialsVolume 36, Issue 13 2470095 FrontispieceFree Access A CTL-Inspired Killing System Using Ultralow-Dose Chemical-Drugs to Induce a Pyroptosis-Mediated Antitumor Immune Function (Adv. Mater. 13/2024) Hao Yin, Hao Yin Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang, 305006 P. R. ChinaSearch for more papers by this authorCongying Xie, Congying Xie Department of Radiation and Medical Oncology, Wenzhou Key Laboratory of Basic Science and Translational Research of Radiation Oncology, Zhejiang Engineering Research Center for Innovation and Application of Intelligent Radiotherapy Technology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 305006 P. R. ChinaSearch for more papers by this authorZhigui Zuo, Zhigui Zuo Department of Colorectal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 305006 P. R. ChinaSearch for more papers by this authorDanli Xie, Danli Xie Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang, 305006 P. R. ChinaSearch for more papers by this authorQinyang Wang, Qinyang Wang Department of Radiation and Medical Oncology, Wenzhou Key Laboratory of Basic Science and Translational Research of Radiation Oncology, Zhejiang Engineering Research Center for Innovation and Application of Intelligent Radiotherapy Technology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 305006 P. R. China Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang, 305006 P. R. ChinaSearch for more papers by this author Hao Yin, Hao Yin Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang, 305006 P. R. ChinaSearch for more papers by this authorCongying Xie, Congying Xie Department of Radiation and Medical Oncology, Wenzhou Key Laboratory of Basic Science and Translational Research of Radiation Oncology, Zhejiang Engineering Research Center for Innovation and Application of Intelligent Radiotherapy Technology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 305006 P. R. ChinaSearch for more papers by this authorZhigui Zuo, Zhigui Zuo Department of Colorectal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 305006 P. R. ChinaSearch for more papers by this authorDanli Xie, Danli Xie Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang, 305006 P. R. ChinaSearch for more papers by this authorQinyang Wang, Qinyang Wang Department of Radiation and Medical Oncology, Wenzhou Key Laboratory of Basic Science and Translational Research of Radiation Oncology, Zhejiang Engineering Research Center for Innovation and Application of Intelligent Radiotherapy Technology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 305006 P. R. China Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang, 305006 P. R. ChinaSearch for more papers by this author First published: 28 March 2024 https://doi.org/10.1002/adma.202470095AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract Antitumor Immunotherapy In article 2309839, Qinyang Wang and co-workers have developed a CTL-inspired system that mimics the process of T-cells attacking tumour cells. The system delivers chemotherapeutic drugs to cancer cells under the control of NIR light. The researchers found that this killing system enables an ultra-low dose of chemotherapeutic drugs to trigger pyroptosis-mediated anti-tumour immune function, leading to tumour regression. Volume36, Issue13March 28, 20242470095 RelatedInformation