Aggregation-Induced Emission Effect-Based Metal –Organic Framework Flower Fluorescent Sensor for Deferasirox and Tigecycline Detection

荧光 化学 发光 组合化学 光化学 材料科学 光电子学 量子力学 物理
作者
Xiaowen Xu,Hui Lin,Bixia Lin,Lingyi Huang,Pingping Wu,Yuxin Wu,Liying Huang
标识
DOI:10.2139/ssrn.4421967
摘要

Deferasirox (DEF) is essential for patients with thalassemia requiring long-term transfusion therapy. Tigecycline (TIGE) is a first-line drug for the clinical treatment of complex, severe bacterial infections. Easy and efficient techniques for monitoring these two drugs in biological samples are few. Metal–organic framework (Zn-MOF) prepared from zinc nitrate hexahydrate and dithioglycolic acid has a flower structure. Interestingly, Zn-MOF can cause DEF to aggregate on it and induce DEF luminescence. The principle may be that Zn-MOF limits the vibration and rotation of DEF to avoid its nonradiative jump, which triggers aggregation-induced emission (AIE) and exhibits intense fluorescence. Further investigation revealed that TIGE could decompose Zn-MOF, thus alleviating the inhibitory effect of Zn-MOF on DEF and reducing the fluorescence intensity of DEF@Zn-MOF. A DEF/TIGE detection biosensor was created based on the fluorescence "turn-on" effect of Zn-MOF on DEF and the fluorescence "turn-off" effect of TIGE on DEF@Zn-MOF. The proposed technique was subsequently used to identify DEF/TIGE levels in pharmaceuticals and human plasma. The recovery rates were 104.32%–104.64% for DEF dispersible and 102.4%–106.5% for TIGE injection The detection limits for the fluorescence detection of DEF and TIGE were 3.6 and 1.2 nM, respectively. This fluorescence assay is the first application of MOF to the simultaneous detection of DEF and TIGE and has the advantages of rapid sensitivity and high selectivity, providing a new strategy for drug detection.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
小马甲应助香蕉采纳,获得10
1秒前
DyG完成签到,获得积分10
1秒前
高序发布了新的文献求助10
2秒前
3秒前
3秒前
yan完成签到,获得积分10
3秒前
菡菡菡菡菡完成签到,获得积分10
3秒前
honey完成签到,获得积分10
3秒前
天天快乐应助檀熹采纳,获得10
4秒前
沉积岩完成签到,获得积分10
4秒前
沧浪江发布了新的文献求助10
4秒前
汉堡包应助蓝桉采纳,获得10
4秒前
silstorm完成签到,获得积分10
5秒前
金东华完成签到,获得积分10
5秒前
妮妮爱smile完成签到,获得积分10
5秒前
南有乔木发布了新的文献求助10
5秒前
5秒前
zly完成签到,获得积分10
5秒前
失眠夏山完成签到,获得积分10
6秒前
junfeiwang发布了新的文献求助10
6秒前
6秒前
背后梦安完成签到,获得积分10
6秒前
7秒前
chen完成签到,获得积分10
8秒前
8秒前
8秒前
嗒嗒完成签到,获得积分10
9秒前
失眠的耳机完成签到,获得积分10
9秒前
9秒前
10秒前
关显锋发布了新的文献求助10
10秒前
champion完成签到,获得积分10
11秒前
11秒前
Owen应助包容的水壶采纳,获得10
11秒前
WANG给WANG的求助进行了留言
12秒前
善良天抒发布了新的文献求助10
12秒前
LLC发布了新的文献求助10
12秒前
huangjie发布了新的文献求助10
13秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969033
求助须知:如何正确求助?哪些是违规求助? 3513900
关于积分的说明 11170818
捐赠科研通 3249256
什么是DOI,文献DOI怎么找? 1794708
邀请新用户注册赠送积分活动 875326
科研通“疑难数据库(出版商)”最低求助积分说明 804759