母子转换
生物
转录组
重编程
核糖体分析
同源盒
非翻译区
细胞生物学
遗传学
小RNA
基因
核糖核酸
翻译(生物学)
基因表达
信使核糖核酸
合子
胚胎发生
作者
Zhuoning Zou,Chuanxin Zhang,Qiuyan Wang,Zhenzhen Hou,Zhuqing Xiong,Feng Kong,Q. Wang,Jinzhu Song,Boyang Liu,Bofeng Liu,Lijuan Wang,Fang-Nong Lai,Qiang Fan,Wenrong Tao,Shuai Zhao,Xiaonan Ma,Miao Li,Keliang Wu,Han Zhao,Zi‐Jiang Chen
出处
期刊:Science
[American Association for the Advancement of Science]
日期:2022-09-08
卷期号:378 (6615): abo7923-abo7923
被引量:177
标识
DOI:10.1126/science.abo7923
摘要
knockdown leads to defective ZGA and preimplantation development. Ectopically expressed TPRXs bind and activate key ZGA genes in human embryonic stem cells. These data reveal the conservation and divergence of translation landscapes during OET and identify critical regulators of human ZGA.
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