达玛烷
化学
三萜类
楝科
传统医学
树皮(声音)
萜烯
抗菌活性
三萜
立体化学
植物
细菌
生物
医学
生态学
遗传学
替代医学
病理
作者
Lili Shao,Hanfei Liu,Huayong Lou,Fengwei Ma,Chao Chen,Jin‐Yu Li,Wei-Dong Pan
出处
期刊:Tetrahedron
[Elsevier]
日期:2022-09-01
卷期号:123: 132987-132987
被引量:2
标识
DOI:10.1016/j.tet.2022.132987
摘要
Eight previously undescribed triterpenoids, including four dammarane-type triterpenoids, named meliasenans A−D ( 1 – 4 ), four apotirucallane-type triterpenoids, named meliasenans E−H ( 5 – 8 ), along with nine known analogues ( 9 – 17 ) have been isolated from the stem bark of Melia toosendan . The structures of the new compounds were elucidated by IR, HRESIMS, 1D, 2D NMR, electronic circular dichroism (ECD) calculations, as well as single-crystal X-ray diffraction analysis. The results of bioassay showed that the new compounds 7 and 8 exhibited potential antibacterial effect on Pseudomonas solanacearum and Bacillus gasoformans, with MIC values of 117.2 μg mL −1 and 118 μg mL −1 , respectively. Moreover, 8 and 11 showed apparent antibacterial activities against Bacillus subtilis (ATCC 6051) with MIC values of 118 μg mL −1 and 92.1 μg mL −1 , respectively. Eight previously undescribed and nine known triterpenoids were isolated from the stem bark of Melia toosendan . • Eight undescribed and nine known triterpenoids were isolated from Melia toosendan. • Their structures were elucidated by spectroscopic methods and X-ray diffraction. • Meliasenan G and Meliasenan H showed weak antibacterial activity.
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