Comparison of [68Ga]Ga-FAPI and [18F]FDG uptake in patients with gastric signet-ring-cell carcinoma: a multicenter retrospective study

医学 印戒细胞 介入放射学 核医学 多中心研究 印戒细胞癌 回顾性队列研究 神经组阅片室 放射科 内科学 癌症 腺癌 神经学 精神科 随机对照试验
作者
Haojun Chen,Yizhen Pang,Junpeng Li,Fei Kang,Weizhi Xu,Tinghua Meng,Qihang Shang,Jun Zhao,Yihui Guan,Hua Wu,Fang Xie,Jing Wang,Long Sun
出处
期刊:European Radiology [Springer Science+Business Media]
卷期号:33 (2): 1329-1341 被引量:35
标识
DOI:10.1007/s00330-022-09084-9
摘要

ObjectiveIn this study, we investigated the role of [68Ga]Ga-FAPI PET imaging in the detection of primary and metastatic gastric signet-ring-cell carcinoma (GSRCC) and compared with [18F]FDG PET.MethodsThis retrospective multicenter analysis included 34 patients with histologically confirmed GSRCCs from four medical centers. The maximum standard uptake value (SUVmax), tumor-to-background ratio (TBR), and diagnostic accuracy were compared between the two modalities. [18F]FDG and [68Ga]Ga-FAPI uptakes were compared by using the Wilcoxon signed-rank test. McNemar’s test was used to compare the diagnostic accuracy between the two techniques.ResultsData were analyzed from 27 paired PET/CT and 7 paired PET/MRI scans for 34 GSRCC patients (16 men and 18 women) who had a median age of 51 years (range: 25–85 years). [68Ga]Ga-FAPI PET showed higher SUVmax and TBR values than did [18F]FDG PET in the primary tumors (SUVmax: 5.2 vs. 2.2, p = 0.001; TBR: 7.6 vs. 1.3, p < 0.001), involved lymph nodes (SUVmax: 6.8 vs. 2.5, p < 0.001; TBR: 5.8 vs. 1.3, p < 0.001), and bone and visceral metastases (SUVmax: 6.5 vs. 2.4, p < 0.001; TBR: 6.3 vs. 1.3, p < 0.001). In diagnostic performance, [68Ga]Ga-FAPI PET exhibited higher sensitivity than [18F]FDG PET for detecting primary tumors (73% [16/22] vs. 18% [4/22], p < 0.001), local recurrences (100% [7/7] vs. 29% [2/7], p = 0.071), lymph node metastases (77% [59/77] vs. 23% [18/77], p < 0.001), and distant metastases (93% [207/222] vs. 39% [86/222], p < 0.001).ConclusionThe results from this multicenter retrospective analysis justify the clinical use of [68Ga]Ga-FAPI tracers for GSRCC diagnosis and staging.Key Points• [68Ga]Ga-FAPI PET/CT is a promising imaging modality for the detection of primary and metastatic disease and has implications for TNM staging in GSRCC.• In this multicenter study of 34 patients with GSRCC, [68Ga]Ga-FAPI PET exhibited greater radiotracer uptake, tumor-to-background ratios, and diagnostic accuracy than [18F]FDG PET for detecting primary/recurrent tumors and metastatic lesions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
2秒前
天天快乐应助一一采纳,获得10
3秒前
炙热的雪糕完成签到,获得积分10
3秒前
4秒前
心心0521发布了新的文献求助10
6秒前
pluto应助刘济源采纳,获得10
6秒前
FIN应助15采纳,获得10
6秒前
内向士萧发布了新的文献求助10
7秒前
abcdulla777完成签到,获得积分20
7秒前
8秒前
SYLH应助元狩采纳,获得10
9秒前
DUANYALI完成签到,获得积分10
9秒前
12秒前
马玲完成签到,获得积分10
12秒前
12秒前
13秒前
iwwwwwn完成签到,获得积分20
13秒前
123发布了新的文献求助10
13秒前
15完成签到,获得积分10
15秒前
啊露发布了新的文献求助10
16秒前
可乐发布了新的文献求助10
17秒前
17秒前
科研通AI5应助iwwwwwn采纳,获得10
19秒前
20秒前
20秒前
酷波er应助htWu采纳,获得10
22秒前
虚拟的惜筠发布了新的文献求助150
24秒前
烟花应助LONG采纳,获得10
24秒前
粗心的易云完成签到 ,获得积分10
24秒前
24秒前
传奇3应助123采纳,获得30
25秒前
Yuying发布了新的文献求助10
26秒前
也曦完成签到 ,获得积分20
28秒前
28秒前
Saman发布了新的文献求助10
29秒前
31秒前
大个应助wuxunxun2015采纳,获得10
32秒前
33秒前
xdy完成签到 ,获得积分10
34秒前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
Production Logging: Theoretical and Interpretive Elements 3000
CRC Handbook of Chemistry and Physics 104th edition 1000
Izeltabart tapatansine - AdisInsight 600
Introduction to Comparative Public Administration Administrative Systems and Reforms in Europe, Third Edition 3rd edition 500
Distinct Aggregation Behaviors and Rheological Responses of Two Terminally Functionalized Polyisoprenes with Different Quadruple Hydrogen Bonding Motifs 450
THE STRUCTURES OF 'SHR' AND 'YOU' IN MANDARIN CHINESE 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3761949
求助须知:如何正确求助?哪些是违规求助? 3305642
关于积分的说明 10135083
捐赠科研通 3019747
什么是DOI,文献DOI怎么找? 1658374
邀请新用户注册赠送积分活动 792030
科研通“疑难数据库(出版商)”最低求助积分说明 754783