医学
明胶海绵
栓塞
明胶
微球
生理盐水
外科
麻醉
化学工程
生物化学
工程类
化学
作者
Hirotatsu Sato,Tetsuo Sonomura,Masataka Koike,Ibu Matsuzaki,Ryuki Shimono,Hiroki Furotani,Shin‐ichi Murata
标识
DOI:10.1016/j.jvir.2022.05.025
摘要
The purpose of this study was to compare complications and the number of ghrelin-expressing cells (GECs) after bariatric arterial embolization (BAE) using soluble gelatin sponge particles (SGSs) or tris-acryl gelatin microspheres (MSs) in swine. Twelve swine underwent embolization of gastric fundal arteries with SGSs (n = 4) or MSs (n = 4) or underwent saline infusion (n = 4, control group). One week later, the number of gastric ulcers and the percentage of GECs were compared among the 3 groups. There were no ulcers in the SGS and control groups. Two swine in the MS group had 4 large ulcers (12-50 mm in size). The mean percentages of GECs were significantly lower in the SGS (2.7% ± 0.9%) and MS (2.5% ± 1.0%) groups compared with the control group (3.7% ± 1.3%; P = .038 and P = .016, respectively). SGSs may be safer than MSs for BAE while inducing a similar reduction of GECs in swine.
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