Characterization of Genetic Risk of End-Stage Knee Osteoarthritis Treated with Total Knee Arthroplasty

医学 优势比 骨关节炎 生命银行 置信区间 体质指数 关节置换术 阶段(地层学) 内科学 全膝关节置换术 逻辑回归 人口 外科 生物信息学 病理 生物 古生物学 替代医学 环境卫生
作者
Scott Kulm,David A. Kolin,Mark T. Langhans,Austin C. Kaidi,Olivier Elemento,Mathias P. Bostrom,Tony S. Shen
出处
期刊:Journal of Bone and Joint Surgery, American Volume [Wolters Kluwer]
卷期号:104 (20): 1814-1820 被引量:10
标识
DOI:10.2106/jbjs.22.00364
摘要

End-stage knee osteoarthritis (OA) is a highly debilitating disease for which total knee arthroplasty (TKA) serves as an effective treatment option. Although a genetic component to OA in general has been described, evaluation of the genetic contribution to end-stage OA of the knee is limited. To this end, we present a genome-wide association study involving patients undergoing TKA for primary knee OA to characterize the genetic features of severe disease on a population level.Individuals with the diagnosis of knee OA who underwent primary TKA were identified in the U.K. Biobank using administrative codes. The U.K. Biobank is a data repository containing prospectively collected clinical and genomic data for >500,000 patients. A genome-wide association analysis was performed using the REGENIE software package. Logistic regression was also used to compare the total genetic risk between subgroups stratified by age and body mass index (BMI).A total of 16,032 patients with end-stage knee OA who underwent primary TKA were identified. Seven genetic loci were found to be significantly associated with end-stage knee OA. The odds ratio (OR) for developing end-stage knee OA attributable to genetics was 1.12 (95% confidence interval [CI], 1.10 to 1.14), which was lower than the OR associated with BMI (OR = 1.81; 95% CI, 1.78 to 1.83) and age (OR = 2.38; 95% CI, 2.32 to 2.45). The magnitude of the OR for developing end-stage knee OA attributable to genetics was greater in patients <60 years old than in patients ≥60 years old (p = 0.002).This population-level genome-wide association study of end-stage knee OA treated with primary TKA was notable for identifying multiple significant genetic variants. These loci involve genes responsible for cartilage development, cartilage homeostasis, cell signaling, and metabolism. Age and BMI appear to have a greater impact on the risk of developing end-stage disease compared with genetic factors. The genetic contribution to the development of severe disease is greater in younger patients.Prognostic Level III . See Instructions for Authors for a complete description of levels of evidence.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
xiaoguan完成签到,获得积分10
1秒前
Owen应助欣喜的尔曼采纳,获得10
3秒前
独特的翠芙完成签到,获得积分10
3秒前
4秒前
5秒前
6秒前
姜惠完成签到 ,获得积分10
6秒前
小脸红扑扑完成签到 ,获得积分10
7秒前
奋斗的凡完成签到 ,获得积分10
7秒前
8秒前
zhutier完成签到,获得积分10
9秒前
wrr完成签到,获得积分10
9秒前
WxChen完成签到,获得积分10
9秒前
开朗艳一完成签到,获得积分10
11秒前
Wonder完成签到,获得积分10
12秒前
yang完成签到,获得积分10
14秒前
123123完成签到 ,获得积分10
15秒前
温暖宛筠完成签到,获得积分10
15秒前
小欣6116完成签到,获得积分10
16秒前
请叫我风吹麦浪应助冬月采纳,获得10
16秒前
LIUYONG发布了新的文献求助10
17秒前
17秒前
肖雪依完成签到,获得积分10
17秒前
影子完成签到,获得积分10
18秒前
19秒前
晨珂完成签到,获得积分10
19秒前
Florencia发布了新的文献求助10
21秒前
xiezhuochun发布了新的文献求助10
22秒前
22秒前
同瓜不同命完成签到,获得积分10
24秒前
牛马哥发布了新的文献求助10
25秒前
温婉的松鼠完成签到,获得积分10
25秒前
26秒前
辛勤的寄瑶完成签到,获得积分10
26秒前
Lauren完成签到 ,获得积分10
27秒前
28秒前
忆枫完成签到,获得积分10
32秒前
炒鸡小将发布了新的文献求助10
32秒前
花壳在逃野猪完成签到 ,获得积分10
32秒前
32秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038303
求助须知:如何正确求助?哪些是违规求助? 3576013
关于积分的说明 11374210
捐赠科研通 3305780
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029