A nested case-control study of serum zinc and incident diabetes among Chinese adults: Effect modifications and mediation analysis

四分位数 套式病例对照研究 糖尿病 体质指数 医学 调解 内科学 优势比 置信区间 人口 内分泌学 环境卫生 政治学 法学
作者
Jing Yang,Zhiyuan Cheng,Desheng Zhang,Tongzhang Zheng,Chun Yin,Simin Liu,Lizhen Zhang,Zhongge Wang,Yufeng Wang,Ruirui Chen,Qian Dou,Yana Bai
出处
期刊:Science of The Total Environment [Elsevier BV]
卷期号:910: 168678-168678 被引量:4
标识
DOI:10.1016/j.scitotenv.2023.168678
摘要

Although numerous evidences suggest that zinc may have a beneficial impact on preventing and treating diabetes, findings from the population studies are inconclusive. To address this gap, we conducted a nested case-control study, employing restricted cubic splines and a conditional logistic regression model to explore the association between serum zinc levels and the risk of diabetes. We also assessed potential effect modifications through stratified analyses and examined the mediating effects of metabolic indicators using a multiclass mediation effect model. We measured baseline serum zinc concentrations using Inductively Coupled Plasma Mass Spectrometry in a cohort of 2156 participants, including 1078 individuals with diabetes and 1078 matched controls. Our findings revealed a 51 % increased risk of diabetes when comparing the highest quartile (Q4) to the lowest quartile (Q1) of serum zinc levels (Odds Ratio [95 % Confidence Interval]: 1.51 [1.09, 2.09]). There was a positive linear dose-response relationship between serum zinc and diabetes risk (P overall ≤0.01, P nonlinear = 0.20). Effect modifications were evident between serum zinc and factors such as educational attainment, body mass index, alcohol index, family history of diabetes, history of hypertension, coronary heart disease, and stroke, all of which influenced the risk of diabetes (all P-interaction <0.05). Moreover, our study identified significant indirect effects of triglycerides levels on diabetes risk for participants in the third (Q3) and fourth (Q4) quartiles of serum zinc, with mediation proportions of 19.23 % and 19.28 %, respectively. A significant indirect effect of alanine aminotransferase on diabetes risk was found for those in the Q4 of serum zinc, with a mediation proportion of 12.05 %. Considering these findings, it is advisable to conduct testing for serum zinc level and exercise caution when considering zinc supplementation. Furthermore, our results emphasized the necessity for additional validation through large-sample prospective population studies and experimental research.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
tianmeiling发布了新的文献求助10
刚刚
一枚小豆发布了新的文献求助10
1秒前
2秒前
NoMi完成签到,获得积分20
3秒前
nines完成签到 ,获得积分10
3秒前
3秒前
量子星尘发布了新的文献求助150
3秒前
5秒前
GUESSSS发布了新的文献求助10
6秒前
欣欣子发布了新的文献求助10
6秒前
12秒前
14秒前
斯文败类应助郑zhenglanyou采纳,获得10
15秒前
haha发布了新的文献求助10
17秒前
甘博发布了新的文献求助10
17秒前
17秒前
19秒前
壮观的衫发布了新的文献求助10
21秒前
21秒前
深情安青应助Ai_niyou采纳,获得10
21秒前
星星的梦完成签到,获得积分10
22秒前
完美世界应助Kelsey采纳,获得10
22秒前
魏笑白发布了新的文献求助10
24秒前
酷波er应助shenxian82133采纳,获得10
25秒前
uppnice发布了新的文献求助10
26秒前
SciGPT应助端庄的学姐采纳,获得10
26秒前
棣棣完成签到,获得积分10
27秒前
27秒前
壮观的衫完成签到,获得积分10
27秒前
sgt完成签到,获得积分10
28秒前
坦率夕阳完成签到,获得积分10
29秒前
30秒前
avc完成签到,获得积分10
30秒前
haha完成签到,获得积分10
31秒前
大模型应助拟好啊采纳,获得10
31秒前
33秒前
CipherSage应助uppnice采纳,获得10
35秒前
独白发布了新的文献求助10
35秒前
36秒前
avc发布了新的文献求助10
37秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975661
求助须知:如何正确求助?哪些是违规求助? 3520000
关于积分的说明 11200535
捐赠科研通 3256410
什么是DOI,文献DOI怎么找? 1798247
邀请新用户注册赠送积分活动 877490
科研通“疑难数据库(出版商)”最低求助积分说明 806390