Synthesis of some Curcumin derivatives of Non-Steroidal Anti-Inflammatory (NSAIDs) Prodrugs for Treatment of Inflammatory Bowel Diseases

前药 姜黄素 炎症性肠病 溃疡性结肠炎 消炎药 医学 药理学 炎症性肠病 化学 内科学 疾病
作者
Yogendra Kumar,Nidhi Agrawal,Meenakshi Jaiswal
出处
期刊:Research journal of pharmacy and technology [Diva Enterprises Private Limited]
卷期号:: 2733-2740
标识
DOI:10.52711/0974-360x.2023.00449
摘要

Inflammatory Bowel Disease (IBD) is the most prevalent chronic gastrointestinal disorder in children and adolescents. IBD is a collection of recurrent and remitting inflammatory gastrointestinal illnesses that mostly includes ulcerative colitis (UC) and Crohn's disease (CD). Amino salicylates, corticosteroids, and biological agents are drugs that are now utilized to treat inflammatory bowel disorders. The research envisaged and plan of work to be carried out can be summarized as adetailed review of curcumin derivatives, synthesis of compound and their derivatives, physio-chemical properties, structure elucidation, and biological evaluation of synthesized compounds for anti-inflammatory potential. Prodrugs are synthesized by conjugation of NSAID derivatives with some curcumin derivatives by the reflux in different solvents in the presence of thionyl chloride as an acid catalyst.The synthetic compounds YK-01 and YK-02 were obtained in a series. The FTIR, NMRspectroscopy, and other physiochemical properties have characterized the structure of the synthesized prodrugs. The anti-inflammatory activity of the synthesized compounds was tested in a carrageenan-induced rat paw oedema model, and it was discovered that the prodrugs treated compound (YK-02) showed decreased inflammation and paw oedema volume, as well as a better activity than synthesized prodrugs (YK-01).

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