肿瘤微环境
免疫抑制
缺氧(环境)
化学
放射治疗
光动力疗法
免疫疗法
癌症研究
转移
药物输送
血管生成
肿瘤缺氧
免疫系统
肿瘤细胞
免疫学
医学
癌症
内科学
有机化学
氧气
作者
Hao Lin,Lianzhou Wang,Yichuan Ma,Massimo Bottini,Luwei Li,Hong‐Bo Cheng,Shutao Gao,Xing‐Jie Liang,Jinchao Zhang
标识
DOI:10.1016/j.ccr.2023.215482
摘要
Hypoxia is a hallmark of solid tumors and it significantly contributes to the development of key biological features of tumors, including the microenvironment, migration, invasion, metastasis, pathological angiogenesis, drug resistance, immunosuppression, and poor prognosis. Hypoxia hampers the efficacy of current anti-tumor approaches, including radiotherapy, chemotherapy, immunotherapy, and photodynamic therapy. This has fueled the development of nanomaterials to reoxygenate the tumor’s microenvironment by delivering exogenous O2 or generating O2 in situ as therapeutic approaches per se or to improve the efficacy of current anti-tumor approaches. Herein, we review the recent research progress of nanomaterials for O2 delivery and generation in situ. Their potential transition to the clinics is also discussed.
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