亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Lipid emulsion therapy during management of the critically-ill poisoned patient: a prospective cohort study

四分位间距 医学 血压 队列 亲脂性 内科学 生理学 生物 生物化学
作者
Michael Levine,Jeffrey Brent,Timothy J. Wiegand,Bryan Maguire,Neta Cohen,David Vaerrier,Michael C. Beuhler,Jerrold B. Leikin,Michael Ganetsky,Samuel J. Stellpflug,Anne‐Michelle Ruha,Jennifer Carey,Ann-Jeannette Geib,Dazhe Cao,Kurt Kleinschmidt,Rais Vohra,Brad Riley,Phillip Moore,Evan S. Schwarz,Mark Neavyn,Daniel E. Rusyniak,Spencer Greene,Joshua Nogar,Alex F. Manini,Mary Wermuth,Anthony F. Pizon,Robert G. Hendrickson,Matthew K. Griswold,Kim Aldy,Paul M. Wax,Meghan B. Spyres,Sharan Campleman,Erin M. Macdonald,Yaron Finkelstein
出处
期刊:Clinical Toxicology [Taylor & Francis]
卷期号:61 (8): 584-590 被引量:5
标识
DOI:10.1080/15563650.2023.2248372
摘要

Despite conflicting data, intravenous lipid emulsion has emerged as a potential antidote. The "lipid sink" theory suggests that following intravenous administration of lipid, lipophilic drugs are sequestered in the vascular compartment, thereby reducing their tissue concentrations. This study sought to determine if survival is associated with the intoxicant's degree of lipophilicity.We reviewed all cases in the Toxicology Investigators Consortium's lipid sub-registry between May 2012 through December 2018. Information collected included demographics, exposure circumstances, clinical course, management, disposition, and outcome. The primary outcome was survival after lipid emulsion therapy. Survival was stratified by the log of the intoxicant's octanol-water partition coefficient. We also assessed the association between intoxicant lipophilicity and an increase in systolic blood pressure after lipid emulsion administration.We identified 134 patients, including 81 (60.4%) females. The median age was 40 years (interquartile range 21-75). One hundred and eight (80.6%) patients survived, including 45 (33.6%) with cardiac arrest during their intoxication. Eighty-two (61.2%) were hypotensive, and 98 (73.1%) received mechanical ventilation. There was no relationship between survival and the log of the partition coefficient of the intoxicant on linear analysis (P = 0.89) or polynomial model (P = 0.10). Systolic blood pressure increased in both groups. The median (interquartile range) systolic blood pressure before lipid administration was 68 (60-78) mmHg for those intoxicants with a log partition coefficient < 3.6 compared with 89 (76-104) mmHg after lipid administration. Among those drugs with a log partition coefficient > 3.6, the median (interquartile range) was 69 (60-84) mmHg before lipid and 89 (80-96) mmHg after lipid administration.Most patients in this cohort survived. Lipophilicity was not correlated with survival or the observed changes in blood pressure. The study did not address the efficacy of lipid emulsion.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
ffdhdh完成签到,获得积分10
13秒前
白天科室黑奴and晚上实验室牛马完成签到 ,获得积分10
1分钟前
1分钟前
Akim应助亦风采纳,获得10
1分钟前
1分钟前
亦风发布了新的文献求助10
1分钟前
情怀应助刘紫媛采纳,获得10
1分钟前
科研通AI2S应助亦风采纳,获得10
1分钟前
亦风完成签到,获得积分10
2分钟前
2分钟前
偷得浮生半日闲完成签到 ,获得积分10
2分钟前
jintian完成签到 ,获得积分10
2分钟前
2分钟前
fufufu123完成签到 ,获得积分10
3分钟前
桐桐应助科研通管家采纳,获得10
3分钟前
puzhongjiMiQ完成签到,获得积分10
3分钟前
4分钟前
李健的粉丝团团长应助lzzz采纳,获得10
5分钟前
5分钟前
刘紫媛发布了新的文献求助10
5分钟前
Raul完成签到 ,获得积分10
5分钟前
lql完成签到 ,获得积分10
6分钟前
可爱的函函应助鲅鱼圈采纳,获得10
6分钟前
6分钟前
lzzz发布了新的文献求助10
6分钟前
英喆完成签到 ,获得积分10
6分钟前
我是老大应助畅快的毛衣采纳,获得10
7分钟前
7分钟前
7分钟前
鲅鱼圈发布了新的文献求助10
7分钟前
7分钟前
Leofar完成签到 ,获得积分10
7分钟前
7分钟前
鲅鱼圈完成签到,获得积分10
7分钟前
h0jian09完成签到,获得积分10
7分钟前
BaooooooMao完成签到,获得积分10
8分钟前
愉快的犀牛完成签到 ,获得积分10
8分钟前
Sunny完成签到,获得积分10
8分钟前
yujie完成签到 ,获得积分10
8分钟前
赘婿应助科研通管家采纳,获得10
9分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990447
求助须知:如何正确求助?哪些是违规求助? 3532166
关于积分的说明 11256513
捐赠科研通 3271046
什么是DOI,文献DOI怎么找? 1805207
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234