癌基因
胶质瘤
串扰
生物
计算生物学
功能(生物学)
癌症
生物信息学
癌症研究
细胞生物学
遗传学
细胞周期
光学
物理
作者
Nan Xiao,Wenming Yang,Jin Wang,Jiarong Li,Ruoxuan Zhao,Muzheng Li,Chi Li,Kang Liu,Yingxin Li,Chaoqun Yin,Zhibo Chen,Xingqi Li,Yun Jiang
出处
期刊:Proteins
[Wiley]
日期:2023-07-27
卷期号:92 (1): 24-36
摘要
Abstract Glioma is a type of tumor that starts in the glial cells of the brain or spine. Since the 1800s, when the disease was first named, its survival rates have always been unsatisfactory. Despite great advances in molecular biology and traditional treatment methods, many questions regarding cancer occurrence and the underlying mechanism remain to be answered. In this study, we assessed the protein structural features of 20 oncogenes and 20 anti‐oncogenes via protein structure and dynamic analysis methods and 3D structural and systematic analyses of the structure–function relationships of proteins. All of these results directly indicate that unfavorable group proteins show more complex structures than favorable group proteins. As the tumor cell microenvironment changes, the balance of oncogene‐related and anti‐oncogene‐related proteins is disrupted, and most of the structures of the two groups of proteins will be disrupted. However, more unfavorable group proteins will maintain and refold to achieve their correct shape faster and perform their functions more quickly than favorable group proteins, and the former thus support cancer development. We hope that these analyses will help promote mechanistic research and the development of new treatments for glioma.
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