Stereodivergent Construction of Contiguous Quaternary Carbon Centers Enabled by Asymmetric Catalysis

Herein, we report the discovery of the catalytic asymmetric conjugated addition of allylstannanes to indol-2-ones promoted by Ni(II)/chiral N,N′-dioxide. This method enables the stereodivergent construction of contiguous quaternary carbon centers (CQCCs), which can be readily achieved by a suitable combination of a chiral catalyst with stereospecific allylstannanes. This protocol allows for a unified access to all stereoisomers of 3,3-disubstituted oxindoles with CQCCs in good to excellent enantioselectivities and diastereoselectivities.