Wnt信号通路
生物
血管生成
旁分泌信号
间充质干细胞
间质细胞
信号转导
细胞生物学
自分泌信号
新生血管
再生医学
癌症研究
干细胞
细胞培养
遗传学
受体
作者
Pratheesh Mankuzhy,Arun Dharmarajan,Lakshmi R. Perumalsamy,Khan Sharun,Priyanka Samji,Rodney J. Dilley
出处
期刊:Tissue & Cell
[Elsevier]
日期:2023-12-01
卷期号:85: 102240-102240
被引量:3
标识
DOI:10.1016/j.tice.2023.102240
摘要
Development, growth, and remodeling of blood vessels occur through an intricate process involving cell differentiation, proliferation, and rearrangement by cell migration under the direction of various signaling pathways. Recent reports highlight that resident and exogenous mesenchymal stromal cells (MSCs) have the potential to regulate the neovascularization process through paracrine secretion of proangiogenic factors. Recent research has established that the vasculogenic potential of MSCs is regulated by several signaling pathways, including the Wnt signaling pathway, and their interplay. These findings emphasize the complex nature of the vasculogenic process and underscore the importance of understanding the underlying molecular mechanisms for the development of effective cell-based therapies in regenerative medicine. This review provides an updated briefing on the canonical and non-canonical Wnt signaling pathways and summarizes the recent reports of both in vitro and in vivo studies with the involvement of MSCs of various sources in the vasculogenic process mediated by Wnt signaling pathways. Here we outline the current understanding of the plausible role of the Wnt signaling pathway, specifically in MSC-regulated angiogenesis.
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