医学
急性呼吸窘迫综合征
急性呼吸窘迫
观察研究
感染性休克
表型
败血症
随机对照试验
重症监护医学
病危
内科学
严重败血症
呼吸窘迫
肺
外科
基因
遗传学
生物
作者
Pratik Sinha,V. Eric Kerchberger,Andrew Willmore,Julia Chambers,Hanjing Zhuo,Jason Abbott,Chayse Jones,Nancy Wickersham,Nelson Wu,Lucile Neyton,Charles Langelier,Eran Mick,June He,Alejandra Jáuregui,Matthew M. Churpek,A.D. Gomez,Carolyn M. Hendrickson,Kirsten N. Kangelaris,Aartik Sarma,Aleksandra Leligdowicz
标识
DOI:10.1016/s2213-2600(23)00237-0
摘要
In sepsis and acute respiratory distress syndrome (ARDS), heterogeneity has contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular phenotypes (hypoinflammatory and hyperinflammatory) have consistently been identified, with divergent outcomes and treatment responses. In this study, we sought to derive molecular phenotypes in critically ill adults with sepsis, determine their overlap with previous ARDS phenotypes, and evaluate whether they respond differently to treatment in completed sepsis trials.
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